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dc.contributor | Facultad de Veterinaria | es_ES |
dc.contributor.author | Mencía Ares, Óscar | |
dc.contributor.author | Argüello Rodríguez, Héctor | |
dc.contributor.author | Puente Fernández, Héctor | |
dc.contributor.author | Gómez García, Manuel | |
dc.contributor.author | Manzanilla, Edgar G. | |
dc.contributor.author | Álvarez Ordóñez, Avelino | |
dc.contributor.author | Carvajal Urueña, Ana María | |
dc.contributor.author | Rubio Nistal, Pedro Miguel | |
dc.contributor.other | Sanidad Animal | es_ES |
dc.date | 2021-03-19 | |
dc.date.accessioned | 2024-01-31T09:37:41Z | |
dc.date.available | 2024-01-31T09:37:41Z | |
dc.identifier.citation | Mencía-Ares, O., Argüello, H., Puente, H., Gómez-García, M., Manzanilla, E. G., Álvarez-Ordóñez, A., Carvajal, A., & Rubio, P. (2021). Antimicrobial resistance in commensal Escherichia coli and Enterococcus spp. is influenced by production system, antimicrobial use, and biosecurity measures on Spanish pig farms. Porcine Health Management, 7(1). https://doi.org/10.1186/S40813-021-00206-1 | es_ES |
dc.identifier.issn | 2055-5660 | |
dc.identifier.other | https://porcinehealthmanagement.biomedcentral.com/articles/10.1186/s40813-021-00206-1 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10612/17946 | |
dc.description.abstract | [EN] Background Antimicrobial resistance (AMR) is a global public health threat consequence of antimicrobial use (AMU) in human and animal medicine. In food-producing animals factors such as management, husbandry or biosecurity may impact AMU. Organic and extensive Iberian swine productions are based on a more sustainable and eco-friendly management system, providing an excellent opportunity to evaluate how sustained differences in AMU impact the AMR in indicator bacteria. Here, we evaluate the usefulness of commensal Escherichia coli and Enterococcus spp. isolates as AMR bioindicators when comparing 37 Spanish pig farms from both intensive and organic-extensive production systems, considering the effect of AMU and biosecurity measures, the last only on intensive farms. Results The production system was the main factor contributing to explain the AMR differences in E. coli and Enterococcus spp. In both bacteria, the pansusceptible phenotype was more common (p < 0.001) on organic-extensive farms when compared to intensive herds. The microbiological resistance in commensal E. coli was, for most of the antimicrobials evaluated, significantly higher (p < 0.05) on intensive farms. In enterococci, the lincosamides usage revealed the association between AMR and AMU, with an increase in the AMR for erythromycin (p < 0.01), quinupristin-dalfopristin (p < 0.01) and the multidrug-resistant (MDR) phenotype (p < 0.05). The biosecurity measures implemented on intensive farms influenced the AMR of these bioindicators, with a slightly lower resistance to sulfamethoxazole (p < 0.01) and the MDR phenotype (p < 0.05) in E. coli isolated from farms with better cleaning and disinfection protocols. On these intensive farms, we also observed that larger herds had a higher biosecurity when compared to smaller farms (p < 0.01), with no significant associations between AMU and the biosecurity scores. Conclusions Overall, this study evidences that the production system and, to a lesser extent, the biosecurity measures, contribute to the AMR development in commensal E. coli and Enterococcus spp., with antimicrobial usage as the main differential factor, and demonstrates the potential value of these bacteria as bioindicators on pig farms in AMR surveillance programs. | es_ES |
dc.language | eng | es_ES |
dc.publisher | BioMed Central Ltd. | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Sanidad animal | es_ES |
dc.subject | Veterinaria | es_ES |
dc.subject.other | Antibiotic usage | es_ES |
dc.subject.other | Bioindicator | es_ES |
dc.subject.other | Enterococcus spp. | es_ES |
dc.subject.other | Escherichia coli | es_ES |
dc.subject.other | One Health | es_ES |
dc.subject.other | Swine | es_ES |
dc.subject.other | Sustainable farming | es_ES |
dc.title | Antimicrobial resistance in commensal Escherichia coli and Enterococcus spp. is influenced by production system, antimicrobial use, and biosecurity measures on Spanish pig farms | es_ES |
dc.title.alternative | La resistencia a los antimicrobianos en Escherichia coli y Enterococcus spp. comensales está influida por el sistema de producción, el uso de antimicrobianos y las medidas de bioseguridad en las explotaciones porcinas españolas | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | https://doi.org/10.1186/s40813-021-00206-1 | |
dc.description.peerreviewed | SI | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 2055-5660 | |
dc.journal.title | Porcine Health Management | es_ES |
dc.volume.number | 7 | es_ES |
dc.issue.number | 27 | es_ES |
dc.page.initial | 1 | es_ES |
dc.page.final | 12 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
dc.subject.unesco | 3109 Ciencias Veterinarias | es_ES |
dc.subject.unesco | 3104.08 Porcinos | es_ES |
dc.description.project | We acknowledge the excellent technical assistance provided by Diana Molina and the contribution in some parts of the research by Sandra González from Aquilón CyL S.L. We would like to thank also the veterinary practitioners and farmers willingness, and in particular Álvaro Fernández-Blanco for his support on contacting the farms. | es_ES |
dc.description.project | The research was funded by an INIA project (RTA2015–00075-c04–03). Oscar Mencía-Ares and Héctor Puente hold a grant from the Spanish Government (Ministerio de Educación y Formación Profesional) FPU 16/03485 and FPU 17/00466. Manuel Gómez-García hold a grant from Junta de Castilla y León co-financed by the European Social Fund (LE131–18). Hector Argüello is financially supported by the “Beatriz Galindo” Programme from the Spanish Government (Ministerio de Educación y Formación Profesional) BEAGAL-18-106. Research in the laboratory of Avelino Alvarez-Ordóñez is funded by the European Commission under European Union’s Horizon 2020 research and innovation program under grant agreement No 818368 and the Ministry of Science and Innovation of the Spanish Government (AGL2016–78085-P). | es_ES |
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