dc.contributor | Facultad de Ciencias de la Salud | es_ES |
dc.contributor.author | Hinchliffe, Alice | |
dc.contributor.author | Kogevinas, Manolis | |
dc.contributor.author | Pérez Gómez, Beatriz | |
dc.contributor.author | Ardanaz, Eva | |
dc.contributor.author | Amiano, Pilar | |
dc.contributor.author | Marcos Delgado, Alba | |
dc.contributor.author | Castaño Vinyals, Gemma | |
dc.contributor.author | Llorca, Javier | |
dc.contributor.author | Moreno, Víctor | |
dc.contributor.author | Alguacil, Juan | |
dc.contributor.author | Fernández Tardón, Guillermo | |
dc.contributor.author | Salas, Dolores | |
dc.contributor.author | Marcos Gragera, Rafael | |
dc.contributor.author | Aragonés, Nuria | |
dc.contributor.author | Guevara, Marcela | |
dc.contributor.author | Gil, Leire | |
dc.contributor.author | Martín Sánchez, Vicente | |
dc.contributor.author | Benavente, Yolanda | |
dc.contributor.author | Gómez Acebo, Inés | |
dc.contributor.author | Santibáñez, Miguel | |
dc.contributor.author | Alba, Miguel Ángel | |
dc.contributor.author | García, Ana M. | |
dc.contributor.author | Pollán, Marina | |
dc.contributor.author | Turner, Michelle C. | |
dc.contributor.other | Medicina Preventiva | es_ES |
dc.date | 2021 | |
dc.date.accessioned | 2024-02-08T12:37:55Z | |
dc.date.available | 2024-02-08T12:37:55Z | |
dc.identifier.citation | Hinchliffe, A., Kogevinas, M., Pérez Gómez, B., Ardanaz, E., Amiano, P., Marcos Delgado, A., Castaño Vinyals, G., Llorca, J., Moreno, V., Alguacil, J., Fernández Tardón, G., Salas, D., Marcos Gragera, R., Aragonés, N., Guevara, M., Gil, L., Martín Sánchez, V., Benavente, Y., Gómez Acebo, I., Santibáñez, M. (2021). Occupational heat exposure and breast cancer risk in the MCC-Spain study. Cancer Epidemiology, Biomarkers & Prevention, 30(2), 364-372. https://doi.org/10.1158/1055-9965.EPI-20-0732 | es_ES |
dc.identifier.issn | 1055-9965 | |
dc.identifier.other | https://aacrjournals.org/cebp/article/30/2/364/72417/Occupational-Heat-Exposure-and-Breast-Cancer-Risk | es_ES |
dc.identifier.uri | https://hdl.handle.net/10612/18195 | |
dc.description.abstract | [EN] Background: Mechanisms linking occupational heat exposure with chronic diseases have been proposed. However, evidence on occupational heat exposure and cancer risk is limited. Methods: We evaluated occupational heat exposure and female breast cancer risk in a large Spanish case-control study. We enrolled 1,738 breast cancer cases and 1,910 frequency-matched population controls. A Spanish job-exposure matrix, MatEmEsp, was used to assign estimates of the proportion of workers exposed (P >= 25% for at least 1 year) and work time with heat stress (wet bulb globe temperature ISO 7243) for each occupation. We used three exposure indices: ever versus never exposed, lifetime cumulative exposure, and duration of exposure (years). We estimated ORs and 95% confidence intervals (CI), applying a lag period of 5 years and adjusting for potential confounders. Results: Ever occupational heat exposure was associated with a moderate but statistically significant higher risk of breast cancer (OR 1.22; 95% CI, 1.01-1.46), with significant trends across categories of lifetime cumulative exposure and duration (P-trend = 0.01 and 0.03, respectively). Stronger associations were found for hormone receptor-positive disease (OR ever exposure = 1.38; 95% Cl, 1.12-1.67). We found no confounding effects from multiple other common occupational exposures; however, results attenuated with adjustment for occupational detergent exposure. Conclusions: This study provides some evidence of an association between occupational heat exposure and female breast cancer risk. | es_ES |
dc.language | eng | es_ES |
dc.publisher | American Association of Cancer Research | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | Medicina. Salud | es_ES |
dc.subject.other | Shock proteins | es_ES |
dc.subject.other | Pancreatic-cancer | es_ES |
dc.subject.other | Aluminum smelter | es_ES |
dc.subject.other | Workers | es_ES |
dc.subject.other | Stress | es_ES |
dc.subject.other | Factor-1 | es_ES |
dc.subject.other | Health | es_ES |
dc.title | Occupational Heat Exposure and Breast Cancer Risk in the MCC-Spain Study | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.1158/1055-9965.EPI-20-0732 | |
dc.description.peerreviewed | SI | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 1538-7755 | |
dc.journal.title | Cancer epidemiology biomarkers & prevention | es_ES |
dc.volume.number | 30 | es_ES |
dc.issue.number | 2 | es_ES |
dc.page.initial | 364 | es_ES |
dc.page.final | 372 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.project | This study was partially funded by the “Accion Transversal del Cancer,” approved by the Spanish Ministry Council on October 11, 2007; the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/1359, PI09/00773, PI09/01286, PI09/01903, PI09/02078, PI09/01662, PI11/01403, PI11/01889, and PI12/00265); the Fundación Marqués de Valdecilla (API 10/09); the Junta de Castilla y León (LE22A10-2); the Consejería de Salud of the Junta de Andalucía (2009-S0143); the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10); the Recercaixa (2010ACUP 00310); the Regional Government of the Basque Country; the Consejería de Sanidad de la Región de Murcia; the European Commission grants FOOD-CT-2006–036224-HIWATE; the Spanish Association Against Cancer (AECC) Scientific Foundation; the Catalan Government DURSI grant 2014SGR647; the Secretariat for Universities and Research of the Ministry of Business and Knowledge of the Government of Catalonia (2017SGR1085); the Fundación Caja de Ahorros de Asturias; and the University of Oviedo. M.C. Turner is funded by a Ramón y Cajal fellowship (RYC-2017-01892) from the Spanish Ministry of Science, Innovation and Universities and co-funded by the European Social Fund. The authors acknowledge support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S) and support from the Generalitat de Catalunya through the CERCA Program. Statistical assistance provided by Ana Espinosa Morano was greatly appreciated. | es_ES |