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Título
Neuroprotective effects of meloxicam on transient brain ischemia in rats: the two faces of anti-inflammatory treatments
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Neural Regeneration Research
Número de la revista
9
Cita Bibliográfica
Ugidos, I.F., González-Rodríguez, P., Santos-Galdiano, M., Font-Belmonte, E., Anuncibay-Soto, B., Pérez-Rodríguez, D., Gonzalo-Orden, J., and Fernández-López, A. (2023). Neuroprotective effects of meloxicam on transient brain ischemia in rats: the two faces of anti-inflammatory treatments. Neural Regeneration Research, 18(9), 1961–1967. https://doi.org/10.4103/1673-5374.367846
Editorial
Wolters Kluwer
Fecha
2023
ISSN
1673-5374
Resumen
[EN] The inflammatory response plays an important role in neuroprotection and regeneration after ischemic insult. The use of non-steroidal anti-inflammatory drugs has been a matter of debate as to whether they have beneficial or detrimental effects. In this context, the effects of the anti-inflammatory agent meloxicam have been scarcely documented after stroke, but its ability to inhibit both cyclooxygenase isoforms (1 and 2) could be a promising strategy to modulate post-ischemic inflammation. This study analyzed the effect of meloxicam in a transient focal cerebral ischemia model in rats, measuring its neuroprotective effect after 48 hours and 7 days of reperfusion and the effects of the treatment on the glial scar and regenerative events such as the generation of new progenitors in the subventricular zone and axonal sprouting at the edge of the damaged area. We show that meloxicam's neuroprotective effects remained after 7 days of reperfusion even if its administration was restricted to the two first days after ischemia. Moreover, meloxicam treatment modulated glial scar reactivity, which matched with an increase in axonal sprouting. However, this treatment decreased the formation of neuronal progenitor cells. This study discusses the dual role of anti-inflammatory treatments after stroke and encourages the careful analysis of both the neuroprotective and the regenerative effects in preclinical studies
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Palabras clave
Peer review
SI
ID proyecto
- info:eu-repo/grantAgreement/MICINN/Programa Estatal para Impulsar la Investigación Científico-Técnica y su Transferencia/CPP2021-008855/ES/LAM226 en el tratamiento de neuropatías: Desarrollo preclínico y nuevos candidatos/(NEUROPAT226)
- info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/RTC-2015-4094-1Q2432001BCASTILLA Y LEON/ES/Desarrollo farmacéutico de lípidos de diseño para el tratamiento del ictus y patologías relacionadas (Metabolopatías)
- info:eu-repo/grantAgreement/JCYL/Programa de apoyo a proyectos de investigación/LE025P17/ES/De las terapias paliativas a las regenerativas en el accidente cerebrovascular
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