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dc.contributor | Facultad de Veterinaria | es_ES |
dc.contributor.author | Blanco Vázquez, Cristina | |
dc.contributor.author | Balseiro Morales, Ana María | |
dc.contributor.author | Alonso Hearn, Marta | |
dc.contributor.author | Juste, Ramón A. | |
dc.contributor.author | Iglesias, Natalia | |
dc.contributor.author | Canive, María | |
dc.contributor.author | Casais, Rosa | |
dc.contributor.other | Sanidad Animal | es_ES |
dc.date | 2021 | |
dc.date.accessioned | 2024-03-13T08:39:46Z | |
dc.date.available | 2024-03-13T08:39:46Z | |
dc.identifier.citation | Blanco Vázquez, C., Balseiro, A., Alonso-Hearn, M., Juste, R. A., Iglesias, N., Canive, M., & Casais, R. (2021). Bovine intelectin 2 expression as a biomarker of paratuberculosis disease progression. Animals, 11(5). https://doi.org/10.3390/ANI11051370 | es_ES |
dc.identifier.other | https://www.mdpi.com/2076-2615/11/5/1370 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10612/18867 | |
dc.description.abstract | [EN]Paratuberculosis (PTB), a chronic granulomatous enteritis caused by Mycobacterium avium subsp. paratuberculosis (MAP), is responsible for important economic losses in the dairy indus-try. Our previous RNA-sequencing (RNA-Seq) analysis showed that bovine intelectin 2 (ITLN2) precursor gene was overexpressed in ileocecal valve (ICV) samples of animals with focal (log2 fold-change = 10.6) and diffuse (log2 fold-change = 6.8) PTB-associated lesions compared to animals without lesions. This study analyzes the potential use of ITLN2, a protein that has been described as fundamental in the innate immune response to infections, as a biomarker of MAP infection. The presence of ITLN2 was investigated by quantitative immunohistochemical analysis of ICV samples of 20 Holstein Friesian cows showing focal (n = 5), multifocal (n = 5), diffuse (n = 5) and no histological lesions (n = 5). Significant differences were observed in the mean number of ITLN2 immunostained goblet and Paneth cells between the three histopathological types and the control. The number of immunolabelled cells was higher in the focal histopathological type (116.9 ± 113.9) followed by the multifocal (108.7 ± 140.5), diffuse (76.5 ± 97.8) and control types (41.0 ± 81.3). These results validate ITLN2 as a post-mortem biomarker of disease progression. | es_ES |
dc.language | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Sanidad animal | es_ES |
dc.subject | Veterinaria | es_ES |
dc.subject.other | Intelectin 2 | es_ES |
dc.subject.other | Biomarker | es_ES |
dc.subject.other | Immunohistochemistry | es_ES |
dc.subject.other | Ileocecal valve | es_ES |
dc.subject.other | Mycobacterium avium subsp. paratuberculosis | es_ES |
dc.subject.other | Paratuberculosis | es_ES |
dc.title | Bovine Intelectin 2 Expression as a Biomarker of Paratuberculosis Disease Progression | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.3390/ani11051370 | |
dc.description.peerreviewed | SI | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/RTA2014-00009-C02-02/ES/Marcadores inmunológicos y genéticos asociados a infecciones latentes o patentes causadas por Mycobacterium avium subsp. Paratuberculosis | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ AEI/ Programa Estatal de I+D+i Orientada a los Retos de la Sociedad/ RTI2018-094192-R-C22/ES/ DESARROLLO DE NUEVOS METODOS DE DIAGNOSTICO BASADOS EN BIOMARCADORES BOVINOS (PROTEINAS) PARA EL DIAGNOSTICO TEMPRANO DE LA PARATUBERCULOSIS BOVINA | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 2076-2615 | |
dc.journal.title | Animals | es_ES |
dc.volume.number | 11 | es_ES |
dc.issue.number | 5 | es_ES |
dc.page.initial | 1370 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
dc.subject.unesco | 3109 Ciencias Veterinarias | es_ES |
dc.subject.unesco | 3109.05 Microbiología | es_ES |
dc.subject.unesco | 3104.02 Bovinos | es_ES |
dc.description.project | This work has been funded by the National Institute for Agricultural Research (INIA RTA- 2014-00009-C02), the Ministerio de Ciencia, Innovación y Universidades (MCIU) and the Agencia Estatal de Investigación (AEI) reference project RTI2018-094192-R-C22 (FEDER co-funded). Cristina Blanco Vázquez and Maria Canive were supported by a grant from Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA, Spain). | es_ES |
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