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Título
Crosstalk between Neospora caninum and the bovine host at the maternal-foetal interface determines the outcome of infection
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Veterinary Research
Número de la revista
1
Cita Bibliográfica
Jiménez-Pelayo, L., García-Sánchez, M., Collantes-Fernández, E., Regidor-Cerrillo, J., Horcajo, P., Gutiérrez-Expósito, D., Espinosa Cerrato, J., Benavides, J., Osoro, K., Pfarrer, C., & Ortega-Mora, L. M. (2020). Crosstalk between Neospora caninum and the bovine host at the maternal-foetal interface determines the outcome of infection. Veterinary research, 51(1), 83. https://doi.org/10.1186/S13567-020-00803-Y
Editorial
BMC
Fecha
2020
Resumen
[EN]Neospora caninum is an apicomplexan cyst-forming parasite that is considered one of the main causes of abortion.
The pathogenic mechanisms associated with parasite virulence at the maternal-foetal interface that are responsible
for the outcome of infection are largely unknown. Here, utilizing placentomes from cattle experimentally infected
with high-virulence (Nc-Spain7) and low-virulence (Nc-Spain1H) isolates, we studied key elements of the innate and
adaptive immune responses, as well as components of the extracellular matrix (ECM), at 10 and 20 days post-infection
(dpi). The low-virulence isolate elicited a robust immune response characterized by upregulation of genes involved
in pathogen recognition, chemokines and pro-inflammatory cytokines, crucial for its adequate control. In addition,
Nc-Spain1H triggered the expression of anti-inflammatory cytokines and other mechanisms implicated in the maintenance
of ECM integrity to ensure foetal survival. In contrast, local immune responses were initially (10 dpi) impaired
by Nc-Spain7, allowing parasite multiplication. Subsequently (20 dpi), a predominantly pro-inflammatory Th1-based
response and an increase in leucocyte infiltration were observed. Moreover, Nc-Spain7-infected placentomes from
animals carrying non-viable foetuses exhibited higher expression of the IL-8, TNF-α, iNOS and SERP-1 genes and lower
expression of the metalloproteases and their inhibitors than Nc-Spain7-infected placentomes from animals carrying
viable foetuses. In addition, profound placental damage characterized by an alteration in the ECM organization in
necrotic foci, which could contribute to foetal death, was found. Two different host-parasite interaction patterns were
observed at the bovine placenta as representative examples of different evolutionary strategies used by this parasite
for transmission to offspring.
Materia
Palabras clave
Peer review
SI
ID proyecto
- info:eu-repo/grantAgreement/MINECO/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/AGL2013-44694-R/ES/VIRULENCIA EN LA NEOSPOROSIS BOVINA: ESTUDIOS IN VIVO E IN VITRO DE LA INTERACCION PARASITO-HOSPEDADOR CON AISLADOS DE BAJA/ALTA VIRULENCIA
- info:eu-repo/grantAgreement/MINECO/Programa Estatal de Promoción del Talento y su Empleabilidad/BES-2014-070723
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