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dc.contributor | Facultad de Veterinaria | es_ES |
dc.contributor.author | González Barrio, David | |
dc.contributor.author | Diezma Díaz, Carlos | |
dc.contributor.author | Tabanera, Enrique | |
dc.contributor.author | Aguado Criado, Elena | |
dc.contributor.author | Pizarro, Manuel | |
dc.contributor.author | González Huecas, Marta | |
dc.contributor.author | Ferre, Ignacio | |
dc.contributor.author | Jiménez Meléndez, Alejandro | |
dc.contributor.author | Criado, Fernando | |
dc.contributor.author | Gutiérrez Expósito, Daniel | |
dc.contributor.author | Ortega Mora, Luis Miguel | |
dc.contributor.author | Álvarez García, Gema | |
dc.contributor.other | Sanidad Animal | es_ES |
dc.date | 2020 | |
dc.date.accessioned | 2024-03-20T09:38:14Z | |
dc.date.available | 2024-03-20T09:38:14Z | |
dc.identifier.citation | González Barrio, D., Diezma Díaz, C., Tabanera, E., Aguado Criado, E., Pizarro, M., González-Huecas, M., Ferre, I., Jiménez Meléndez, A., Criado, F., Gutiérrez Expósito, D., Ortega Mora, L. M., & Álvarez García, G. (2020). Vascular wall injury and inflammation are key pathogenic mechanisms responsible for early testicular degeneration during acute besnoitiosis in bulls. Parasites & vectors, 13(1), 113. https://doi.org/10.1186/S13071-020-3959-9 | es_ES |
dc.identifier.other | https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-020-3959-9 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10612/19123 | |
dc.description.abstract | [EN] BACKGROUND: Bovine besnoitiosis, caused by the apicomplexan parasite Besnoitia besnoiti, is a chronic and debilitating cattle disease that notably impairs fertility. Acutely infected bulls may develop respiratory signs and orchitis, and sterility has been reported in chronic infections. However, the pathogenesis of acute disease and its impact on reproductive function remain unknown. METHODS: Herein, we studied the microscopic lesions as well as parasite presence and load in the testis (pampiniform plexus, testicular parenchyma and scrotal skin) of seven bulls with an acute B. besnoiti infection. Acute infection was confirmed by serological techniques (IgM seropositive results and IgG seronegative results) and subsequent parasite detection by PCR and histological techniques. RESULTS: The most parasitized tissue was the scrotal skin. Moreover, the presence of tachyzoites, as shown by immunohistochemistry, was associated with vasculitis, and three bulls had already developed juvenile tissue cysts. In all animals, severe endothelial injury was evidenced by marked congestion, thrombosis, necrotizing vasculitis and angiogenesis, among others, in the pampiniform plexus, testicular parenchyma and scrotal skin. Vascular lesions coexisted with lesions characteristic of a chronic infection in the majority of bulls: hyperkeratosis, acanthosis and a marked diffuse fibroplasia in the dermis of the scrotum. An intense inflammatory infiltrate was also observed in the testicular parenchyma accompanied by different degrees of germline atrophy in the seminiferous tubules with the disappearance of various strata of germ cells in four bulls. CONCLUSIONS: This study confirmed that severe acute besnoitiosis leads to early sterility that might be permanent, which is supported by the severe lesions observed. Consequently, we hypothesized that testicular degeneration might be a consequence of (i) thermoregulation failure induced by vascular lesions in pampiniform plexus and scrotal skin lesions; (ii) severe vascular wall injury induced by the inflammatory response in the testis; and (iii) blood-testis barrier damage and alteration of spermatogenesis by immunoresponse | es_ES |
dc.language | eng | es_ES |
dc.publisher | BMC | es_ES |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Sanidad animal | es_ES |
dc.subject.other | Besnoitia besnoiti | es_ES |
dc.subject.other | Bull | es_ES |
dc.subject.other | Acute besnoitiosis | es_ES |
dc.subject.other | Testicular degeneration | es_ES |
dc.subject.other | Lesions | es_ES |
dc.title | Vascular wall injury and inflammation are key pathogenic mechanisms responsible for early testicular degeneration during acute besnoitiosis in bulls | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.1186/S13071-020-3959-9 | |
dc.description.peerreviewed | SI | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/ Programa Estatal de Promoción del Talento y su Empleabilidad/ BES-2014-069839/ES/BES-2014-069839// | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MECD/ Programa Estatal de Promoción del Talento y su Empleabilidad/ FPU13/05481/ES/FPU13/05481// | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 1756-3305 | |
dc.journal.title | Parasites & Vectors | es_ES |
dc.volume.number | 13 | es_ES |
dc.issue.number | 1 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
dc.subject.unesco | 3109 Ciencias Veterinarias | es_ES |
dc.description.project | This study was fnanced by the Spanish Ministry of Economy and Competitive‑ ness (AGL-2016-75202-R) and by the Community of Madrid (PLATESA P2018/ BAA-4370). DG-B is funded by the Spanish Ministry of Science through a Juan de la Cierva postdoctoral fellowship (FJCI-2016-27875). CD-D was fnancially supported through a grant from the Spanish Ministry of Economy and Com‑ petitiveness (BES-2014-069839) and AJ-M through a grant from the Spanish Ministry of Education, Culture and Sports (FPU, Grant Number FPU13/05481) | es_ES |
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