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dc.contributor | Facultad de Veterinaria | es_ES |
dc.contributor.author | Martinez, Ileana Z. | |
dc.contributor.author | Pérez Martínez, Claudia | |
dc.contributor.author | Salinas Rodríguez, Luis Manuel | |
dc.contributor.author | Juste, Ramón A. | |
dc.contributor.author | García Marín, Juan Francisco | |
dc.contributor.author | Balseiro Morales, Ana María | |
dc.contributor.other | Sanidad Animal | es_ES |
dc.date | 2020 | |
dc.date.accessioned | 2024-03-20T13:17:38Z | |
dc.date.available | 2024-03-20T13:17:38Z | |
dc.identifier.citation | Martínez, I. Z., Pérez‐martínez, C., Salinas, L. M., Juste, R. A., García Marín, J. F., & Balseiro, A. (2020). Phenotypic characterization of encephalitis and immune response in the brains of lambs experimentally infected with Spanish goat encephalitis virus. Animals, 10(8), Article e1373. https://doi.org/10.3390/ANI10081373 | es_ES |
dc.identifier.other | https://www.mdpi.com/2076-2615/10/8/1373 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10612/19167 | |
dc.description.abstract | [EN]Spanish goat encephalitis virus (SGEV), a novel subtype of tick-borne flavivirus closely related to louping ill virus, causes a neurological disease in experimentally infected goats and lambs. Here, the distribution of microglia, T and B lymphocytes, and astrocytes was determined in the encephalon and spinal cord of eight Assaf lambs subcutaneously infected with SGEV. Cells were identified based on immunohistochemical staining against Iba1 (microglia), CD3 (T lymphocytes), CD20 (B lymphocytes), and glial fibrillary acidic protein (astrocytes). In glial foci and perivascular cu ng areas, microglia were the most abundant cell type (45.4% of immunostained cells), followed by T lymphocytes (18.6%) and B lymphocytes (4.4%). Thalamus, hypothalamus, corpus callosum, and medulla oblongata contained the largest areas occupied by glial foci. Reactive astrogliosis occurred to a greater extent in the lumbosacral spinal cord than in other regions of the central nervous system. Lesions were more frequent on the side of the animal experimentally infected with the virus. Lesions were more severe in lambs than in goats, suggesting that lambs may be more susceptible to SGEV, which may be due to species di erences or to interindividual di erences in the immune response, rather than to di erences in the relative proportions of immune cells. Larger studies that monitor natural or experimental infections may help clarify local immune responses to this flavivirus subtype in the central nervous system. | es_ES |
dc.language | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Sanidad animal | es_ES |
dc.subject | Veterinaria | es_ES |
dc.subject.other | Spanish goat encephalitis virus (SGEV) | es_ES |
dc.subject.other | Goat | es_ES |
dc.subject.other | Lambs | es_ES |
dc.subject.other | Cell population | es_ES |
dc.subject.other | Immunohistochemistry | es_ES |
dc.title | Phenotypic Characterization of Encephalitis and Immune Response in the Brains of Lambs Experimentally Infected with Spanish Goat Encephalitis Virus | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.3390/ani10081373 | |
dc.description.peerreviewed | SI | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Programa Estatal de I+D+i Orientada a los Retos de la Sociedad/RTI2018-096010-B-C21/ES/EL TEJON (MELES MELES) Y LA TUBERCULOSIS ANIMAL EN ESPAÑA: INTERACCION TEJON-BOVINO EN HOTSPOT AREAS Y MEDIDAS DE CONTROL DE LA ENFERMEDAD EN LA INTERFASE | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 2076-2615 | |
dc.journal.title | Animals | es_ES |
dc.volume.number | 10 | es_ES |
dc.issue.number | 8 | es_ES |
dc.page.initial | 1373 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
dc.subject.unesco | 3109 Ciencias Veterinarias | es_ES |
dc.subject.unesco | 3104.07 Ovinos | es_ES |
dc.description.project | This work was partially supported by a FEDER co-funded grant from the Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (E-RTA2013-00013-C04-04), Ministerio de Ciencia, Innovación y Universidades (MCIU) and the Agencia Estatal de Investigación (AEI) reference project RTI2018-096010-B-C21 (FEDER co-funded) and by the Principado de Asturias, PCTI 2018–220 (GRUPIN: IDI2018-000237 and FEDER). Ms. Ileana Z. Martínez was supported by a Fundación Carolina PhD scholarship (2017 call). | es_ES |
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