Compartir
Título
Diet induced changes in the microbiota and cell composition of rabbit gut associated lymphoid tissue (GALT)
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Scientific Reports
Número de la revista
1
Cita Bibliográfica
Arrazuria, R., Pérez, V., Molina, E., Juste, R. A., Khafipour, E., & Elguezabal, N. (2018). Diet induced changes in the microbiota and cell composition of rabbit gut associated lymphoid tissue (GALT). Scientific Reports, 8(1). https://doi.org/10.1038/S41598-018-32484-1
Editorial
Nature Research
Fecha
2018
Resumen
[EN] The gut associated lymphoid tissue (GALT) is the largest immune organ of the body. Although the gut transient and mucosa-associated microbiota have been largely studied, the microbiota that colonizes the GALT has received less attention. The gut microbiome plays an important role in competitive exclusion of pathogens and in development and maturation of immunity. Diet is a key factor affecting the microbiota composition in the digestive tract. To investigate the relation between diet, microbiota and GALT, microbial and cell composition of vermiform appendix (VA) and sacculus rotundus (SR) were studied in two groups of New Zealand white rabbits on different diets. Diet shifted the lymphoid tissue microbiota affecting the presence and/or absence of certain taxa and their abundances. Immunohistochemistry revealed that a higher fibre content diet resulted in M cell hyperplasia and an increase of recently recruited macrophages, whereas T-cell levels remained unaltered in animals on both high fibre and standard diets. These findings indicate that diet has an impact on the microbiota and cell composition of the GALT, which could act as an important microbial recognition site where interactions with beneficial bacteria can take place favouring microbiota replacement after digestive dysregulations
Materia
Palabras clave
Peer review
SI
ID proyecto
- info:eu-repo/grantAgreement/ MINECO/ Programa Nacional de Investigación Fundamental/AGL2012-39818-C02-02/ES/ DESARROLLO DE MODELOS DE PATOGENIA E INMUNIZACION EN PARATUBERCULOSIS//
URI
DOI
Versión del editor
Aparece en las colecciones
- Artículos [4665]
Ficheros en el ítem
Tamaño:
2.262
xmlui.dri2xhtml.METS-1.0.size-megabytes
Formato:
Adobe PDF