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dc.contributor | Facultad de Veterinaria | es_ES |
dc.contributor.author | Sekar, Divya | |
dc.contributor.author | Govene, Luisa | |
dc.contributor.author | Río González, María Luisa del | |
dc.contributor.author | Sirait-Fischer, Evelyn | |
dc.contributor.author | Fink, Annika | |
dc.contributor.author | Brüne, Bernhard | |
dc.contributor.author | Rodríguez Barbosa, José Ignacio | |
dc.contributor.author | Weigert, Andreas | |
dc.contributor.other | Inmunologia | es_ES |
dc.date | 2018 | |
dc.date.accessioned | 2024-04-04T09:12:26Z | |
dc.date.available | 2024-04-04T09:12:26Z | |
dc.identifier.citation | Sekar, D., Govene, L., Del Río, M.-L., Sirait-Fischer, E., Fink, A. F., Brüne, B., Rodriguez-Barbosa, J. I., & Weigert, A. (2018). Downregulation of BTLA on NKT cells promotes tumor immune control in a mouse model of mammary Carcinoma. International Journal of Molecular Sciences, 19(3). https://doi.org/10.3390/IJMS19030752 | es_ES |
dc.identifier.other | https://www.mdpi.com/1422-0067/19/3/752 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10612/19370 | |
dc.description.abstract | [EN] Natural Killer T cells (NKT cells) are emerging as critical regulators of pro- and anti-tumor immunity, both at baseline and in therapeutic settings. While type I NKT cells can promote anti-tumor immunity, their activity in the tumor microenvironment may be limited by negative regulators such as inhibitory immune checkpoints.We observed dominant expression of B- and T-lymphocyte attenuator (BTLA) on type I NKT cells in polyoma middle T oncogene-driven (PyMT) murine autochthonous mammary tumors. Other immune checkpoint receptors, such as programmed cell death 1 (PD-1) were equally distributed among T cell populations. Interference with BTLA using neutralizing antibodies limited tumor growth and pulmonary metastasis in the PyMT model in a therapeutic setting, correlating with an increase in type I NKT cells and expression of cytotoxic marker genes. While therapeutic application of an anti-PD-1 antibody increased the number of CD8+ cytotoxic T cells and elevated IL-12 expression, tumor control was not established. Expression of ZBTB16, the lineage-determining transcription factor of type I NKT cells, was correlated with a favorable patient prognosis in the METABRIC dataset, and BTLA levels were instrumental to further distinguish prognosis in patents with high ZBTB16 expression. Taken together, these data support a role of BTLA on type I NKT cells in limiting anti-tumor immunity | es_ES |
dc.language | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Inmunología | es_ES |
dc.subject.other | Natural killer T cells | es_ES |
dc.subject.other | Inflammation | es_ES |
dc.subject.other | Cancer | es_ES |
dc.title | Downregulation of BTLA on NKT Cells Promotes Tumor Immune Control in a Mouse Model of Mammary Carcinoma | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.3390/IJMS19030752 | |
dc.description.peerreviewed | SI | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 1422-0067 | |
dc.journal.title | International Journal of Molecular Sciences | es_ES |
dc.volume.number | 19 | es_ES |
dc.issue.number | 3 | es_ES |
dc.page.initial | 752 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
dc.subject.unesco | 3109 Ciencias Veterinarias | es_ES |
dc.description.project | The authors thank Praveen Mathoor and Margarete Mijatovic for excellent technical assistance. The authors are supported by Deutsche Forschungsgemeinschaft (SFB 1039 TP B04 and B06; FOR 2438), Deutsche Krebshilfe (70112451), and Else Kröner Fresenius-Foundation (Graduate school Translational Research Innovation—Pharma (TRIP); and Else Kröner Fresenius Graduate School) | es_ES |
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