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dc.contributorFacultad de Veterinariaes_ES
dc.contributor.authorSekar, Divya
dc.contributor.authorGovene, Luisa
dc.contributor.authorRío González, María Luisa del 
dc.contributor.authorSirait-Fischer, Evelyn
dc.contributor.authorFink, Annika
dc.contributor.authorBrüne, Bernhard
dc.contributor.authorRodríguez Barbosa, José Ignacio 
dc.contributor.authorWeigert, Andreas
dc.contributor.otherInmunologiaes_ES
dc.date2018
dc.date.accessioned2024-04-04T09:12:26Z
dc.date.available2024-04-04T09:12:26Z
dc.identifier.citationSekar, D., Govene, L., Del Río, M.-L., Sirait-Fischer, E., Fink, A. F., Brüne, B., Rodriguez-Barbosa, J. I., & Weigert, A. (2018). Downregulation of BTLA on NKT cells promotes tumor immune control in a mouse model of mammary Carcinoma. International Journal of Molecular Sciences, 19(3). https://doi.org/10.3390/IJMS19030752es_ES
dc.identifier.otherhttps://www.mdpi.com/1422-0067/19/3/752es_ES
dc.identifier.urihttps://hdl.handle.net/10612/19370
dc.description.abstract[EN] Natural Killer T cells (NKT cells) are emerging as critical regulators of pro- and anti-tumor immunity, both at baseline and in therapeutic settings. While type I NKT cells can promote anti-tumor immunity, their activity in the tumor microenvironment may be limited by negative regulators such as inhibitory immune checkpoints.We observed dominant expression of B- and T-lymphocyte attenuator (BTLA) on type I NKT cells in polyoma middle T oncogene-driven (PyMT) murine autochthonous mammary tumors. Other immune checkpoint receptors, such as programmed cell death 1 (PD-1) were equally distributed among T cell populations. Interference with BTLA using neutralizing antibodies limited tumor growth and pulmonary metastasis in the PyMT model in a therapeutic setting, correlating with an increase in type I NKT cells and expression of cytotoxic marker genes. While therapeutic application of an anti-PD-1 antibody increased the number of CD8+ cytotoxic T cells and elevated IL-12 expression, tumor control was not established. Expression of ZBTB16, the lineage-determining transcription factor of type I NKT cells, was correlated with a favorable patient prognosis in the METABRIC dataset, and BTLA levels were instrumental to further distinguish prognosis in patents with high ZBTB16 expression. Taken together, these data support a role of BTLA on type I NKT cells in limiting anti-tumor immunityes_ES
dc.languageenges_ES
dc.publisherMDPIes_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectInmunologíaes_ES
dc.subject.otherNatural killer T cellses_ES
dc.subject.otherInflammationes_ES
dc.subject.otherCanceres_ES
dc.titleDownregulation of BTLA on NKT Cells Promotes Tumor Immune Control in a Mouse Model of Mammary Carcinomaes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.3390/IJMS19030752
dc.description.peerreviewedSIes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.essn1422-0067
dc.journal.titleInternational Journal of Molecular Scienceses_ES
dc.volume.number19es_ES
dc.issue.number3es_ES
dc.page.initial752es_ES
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES
dc.subject.unesco3109 Ciencias Veterinariases_ES
dc.description.projectThe authors thank Praveen Mathoor and Margarete Mijatovic for excellent technical assistance. The authors are supported by Deutsche Forschungsgemeinschaft (SFB 1039 TP B04 and B06; FOR 2438), Deutsche Krebshilfe (70112451), and Else Kröner Fresenius-Foundation (Graduate school Translational Research Innovation—Pharma (TRIP); and Else Kröner Fresenius Graduate School)es_ES


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Atribución 4.0 Internacional
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