Mostrar el registro sencillo del ítem

dc.contributorInstituto Universitario de Biomedicina (IBIOMED)es_ES
dc.contributor.authorSeco Calvo, Jesús Ángel 
dc.contributor.authorRuiz Litago, Fátima
dc.contributor.authorEchevarría, Enrique
dc.contributor.authorMartínez Cengotitabengoa, Mónica
dc.contributor.authorJavier, Gil
dc.contributor.authorIrazusta, Jon
dc.contributor.authorGonzález Pinto, Ana María
dc.contributor.otherFisioterapiaes_ES
dc.date2012
dc.date.accessioned2024-04-05T10:59:30Z
dc.date.available2024-04-05T10:59:30Z
dc.identifier.citationSeco Calvo, J. Á.; Ruiz Litago, F.; Echevarría, E.; Martínez Cengotitabengoa, M.; Javier, G.; Irazusta, J.; González Pinto, A. M. (2012). Adaptive response in the antioxidant defence system in the course and outcome in first-episode schizophrenia patients: A 12-months follow-up study. Psychiatry Research, 200, 218-222(2-3), https://doi.org/10.1016/J.PSYCHRES.2012.07.024es_ES
dc.identifier.issn0165-1781
dc.identifier.urihttps://hdl.handle.net/10612/19480
dc.description.abstract[EN] Correlation of plasma antioxidant enzyme activity with the course and outcome in first-episode schizophrenia patients (n=49) was analyzed in order to assess the possible utility of peripheral markers of oxidative stress as prognostic factors. These markers were measured shortly after the onset of schizophrenia, and again 1, 6 and 12 months later. A decrease in catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), and glutathione (GSH) levels and total antioxidant status (TAS), as well as an increase in thiobarbituric acid reactive substances (TBARS), were observed 1 month after (p<0.05). 6-Months later, there was a reduction in TAS, GSH, SOD and GPx, and a increase in TBARS (p<0.05), with a normalization of CAT levels, indicating a persistent alteration of the antioxidant system and the maintenance of oxidative stress. At 12-months, a considerable decrease was observed in TBARS. Additionally, while the level of GPx decreased (p<0.05) further, SOD and GSH levels and TAS were normalizing, indicating a partial regeneration of the antioxidant defence system. These results indicate the possible contribution of oxidative stress to the onset and pathophysiology of schizophrenia, suggesting the involvement of an adaptive response in the antioxidant defence system in the course and outcome in first-episode schizophrenia patients.es_ES
dc.languageenges_ES
dc.publisherElsevieres_ES
dc.subjectFisioterapiaes_ES
dc.subject.otherFirst Psychotic Episodees_ES
dc.subject.otherAntioxidantses_ES
dc.subject.otherSchizophreniaes_ES
dc.subject.otherOxidative Stresses_ES
dc.titleAdaptive response in the antioxidant defence system in the course and outcome in first-episode schizophrenia patients: A 12-months follow-up studyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.1016/J.PSYCHRES.2012.07.024
dc.rights.accessRightsinfo:eu-repo/semantics/closedAccesses_ES
dc.journal.titlePsychiatry Researches_ES
dc.volume.number200es_ES
dc.issue.number2-3es_ES
dc.page.initial218es_ES
dc.page.final222es_ES
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


Ficheros en el ítem

Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem