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dc.contributor | Facultad de Veterinaria | es_ES |
dc.contributor.author | Herrera Uribe, Juber | |
dc.contributor.author | Zaldívar López, Sara | |
dc.contributor.author | Aguilar, Carmen | |
dc.contributor.author | Luque, Cristina | |
dc.contributor.author | Bautista, Rocío | |
dc.contributor.author | Carvajal Urueña, Ana María | |
dc.contributor.author | Claros, M. Gonzalo | |
dc.contributor.author | Garrido, Juan J. | |
dc.contributor.other | Sanidad Animal | es_ES |
dc.date | 2018 | |
dc.date.accessioned | 2024-04-09T07:30:15Z | |
dc.date.available | 2024-04-09T07:30:15Z | |
dc.identifier.citation | Herrera-Uribe, J., Zaldívar-López, S., Aguilar, C., Luque, C., Bautista, R., Carvajal, A., Gonzalo Claros, & Garrido, J. J. (2018). Regulatory role of microRNA in mesenteric lymph nodes after Salmonella Typhimurium infection. Veterinary Research, 49(1) eArticle 9. https://doi.org/10.1186/S13567-018-0506-1 | es_ES |
dc.identifier.other | https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-018-0506-1 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10612/19554 | |
dc.description | © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | es_ES |
dc.description.abstract | [EN] Salmonellosis is a gastrointestinal disease caused by non-typhoidal Salmonella serovars such as Salmonella Typhimurium. This pathology is a zoonosis, and food animals with subclinical infection constitute a vast reservoir for disease. After intestinal colonization, Salmonella Typhimurium reaches mesenteric lymph nodes (MLN), where infection is controlled avoiding systemic spread. Although the molecular basis of this infection has been extensively studied, little is known about how microRNA (miRNA) regulate the expression of proteins involved in the Salmonella-host interaction. Using small RNA-seq, we examined expression profiles of MLN 2 days after infection with Salmonella Typhimurium, and we found 110 dysregulated miRNA. Among them, we found upregulated miR-21, miR-155, miR-150, and miR-221, as well as downregulated miR-143 and miR-125, all of them previously linked to other bacterial infections. Integration with proteomic data revealed 30 miRNA potentially regulating the expression of 15 proteins involved in biological functions such as cell death and survival, inflammatory response and antigenic presentation. The inflammatory response was found increased via upregulation of miRNA such as miR-21 and miR-155. Downregulation of miR-125a/b, miR-148 and miR-1 were identified as potential regulators of MHC-class I components PSMB8, HSP90B1 and PDIA3, respectively. Furthermore, we confirmed that miR-125a is a direct target of immunoproteasome component PSMB8. Since we also found miR-130 downregulation, which is associated with upregulation of HSPA8, we suggest induction of both MHC-I and MHC-II antigen presentation pathways. In conclusion, our study identifies miRNA that could regulate critical networks for antigenic presentation, inflammatory response and cytoskeletal rearrangements. | es_ES |
dc.language | eng | es_ES |
dc.publisher | BMC | es_ES |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Sanidad animal | es_ES |
dc.subject.other | Salmonellosis | es_ES |
dc.subject.other | Salmonella Typhimurium | es_ES |
dc.subject.other | MicroRNA | es_ES |
dc.subject.other | Mesenteric lymph nodes (MLN) | es_ES |
dc.subject.other | Bacterial infections | es_ES |
dc.subject.other | Zoonosis | es_ES |
dc.subject.other | Gastrointestinal disease | es_ES |
dc.title | Regulatory role of microRNA in mesenteric lymph nodes after Salmonella Typhimurium infection | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.1186/S13567-018-0506-1 | |
dc.description.peerreviewed | SI | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN/Programa Nacional de Investigación Fundamental/AGL2011-28904/ES/INMUNOGENOMICA PARA EL ANALISIS MOLECULAR DE LA RESPUESTA INTESTINAL A LA INFECCION EN PORCINO. IDENTIFICACION DE GENES DE RESISTENCIA A LA SAMONELOSIS// | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/AGL2014-54089-R/ES/INTERACCION PATOGENO-HOSPEDADOR EN LA SALMONELOSIS PORCINA. MODULACION DE LA RESPUESTA INMUNE INTESTINAL POR SALMONELLA Y MECANISMOS DE PERSISTENCIA// | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/Programa Nacional de Formación/BES-2012-058642/ES/BES-2012-058642// | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/Programa Estatal de Promoción del Talento y su Empleabilidad/FPDI-2013-15619/ES/FPDI-2013-15619// | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 1297-9716 | |
dc.journal.title | Veterinary Research | es_ES |
dc.volume.number | 49 | es_ES |
dc.issue.number | 1 | es_ES |
dc.page.initial | 9 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
dc.subject.unesco | 2414.04 Bacteriología | es_ES |
dc.subject.unesco | 5312.07 Sanidad | es_ES |
dc.description.project | This work was supported by the Spanish Ministry of Economy and Competitiveness (AGL2011-28904 and AGL2014-54089). JHU is a predoctoral researcher supported by the FPI Research Program of the Spanish Ministry of Economy and Competitiveness (BES-2012-058642). SZL is a postdoctoral researcher supported by the Postdoctoral Trainee Program of the Spanish Ministry of Economy and Competitiveness (FPDI-2013-15619), and a postdoctoral contract co-funded by the XXI University of Cordoba Intramural research Program and the European Regional Development Funds (FEDER). | es_ES |
dc.description.project | We thank Reyes Alvarez for their technical assistance, and the Functional Genomics Core of the Institute for Research in Biomedicine (IRB) Barcelona for performing the library preparation and small RNA sequencing | es_ES |
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