dc.contributor | Facultad de Veterinaria | es_ES |
dc.contributor.author | Koutsoumanis, Konstantinos | |
dc.contributor.author | Allende, Ana | |
dc.contributor.author | Álvarez Ordóñez, Avelino | |
dc.contributor.author | Bolton, Declan | |
dc.contributor.author | Bover‐Cid, Sara | |
dc.contributor.author | Chemaly, Marianne | |
dc.contributor.author | Davies, Robert | |
dc.contributor.author | De Cesare, Alessandra | |
dc.contributor.author | Herman, Lieve | |
dc.contributor.author | Hilbert, Friederike | |
dc.contributor.author | Lindqvist, Roland | |
dc.contributor.author | Nauta, Maarten | |
dc.contributor.author | Ru, Giuseppe | |
dc.contributor.author | Simmons, Marion | |
dc.contributor.author | Skandamis, Panagiotis | |
dc.contributor.author | Suffredini, Elisabetta | |
dc.contributor.author | Andersson, Dan I | |
dc.contributor.author | Bampidis, Vasileios | |
dc.contributor.author | Bengtsson‐Palme, Johan | |
dc.contributor.author | Bouchard, Damien | |
dc.contributor.author | Ferran, Aude | |
dc.contributor.author | Kouba, Maryline | |
dc.contributor.author | López Puente, Secundino | |
dc.contributor.author | López Alonso, Marta | |
dc.contributor.author | Nielsen, Søren Saxmose | |
dc.contributor.author | Pechová, Alena | |
dc.contributor.author | Petkova, Mariana | |
dc.contributor.author | Girault, Sebastien | |
dc.contributor.author | Broglia, Alessandro | |
dc.contributor.author | Guerra, Beatriz | |
dc.contributor.author | Innocenti, Matteo Lorenzo | |
dc.contributor.author | Liébana, Ernesto | |
dc.contributor.author | López Gálvez, Gloria | |
dc.contributor.author | Manini, Paola | |
dc.contributor.author | Stella, Pietro | |
dc.contributor.author | Peixe, Luisa | |
dc.contributor.other | Tecnologia de los Alimentos | es_ES |
dc.date | 2021 | |
dc.date.accessioned | 2024-05-14T07:34:26Z | |
dc.date.available | 2024-05-14T07:34:26Z | |
dc.identifier.citation | Koutsoumanis, K., Allende, A., Álvarez Ordóñez, A., Bolton, D., Bover-Cid, S., Chemaly, M., Davies, R., De Cesare, A., Herman, L., Hilbert, F., Lindqvist, R., Nauta, M., Ru, G., Simmons, M., Skandamis, P., Suffredini, E., Andersson, D. I., Bampidis, V., Bengtsson-Palme, J., et al. (2021). Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 1: Methodology, general data gaps and uncertainties. EFSA Journal, 19(10), Article e6852. https://doi.org/10.2903/J.EFSA.2021.6852 | es_ES |
dc.identifier.issn | 1831-4732 | |
dc.identifier.other | https://efsa.onlinelibrary.wiley.com/doi/full/10.2903/j.efsa.2021.6852 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10612/20690 | |
dc.description.abstract | [EN] The European Commission requested EFSA to assess, in collaboration with EMA, the specific concentrations of antimicrobials resulting from cross-contamination in non-target feed for food-producing animals below which there would not be an effect on the emergence of, and/or selection for, resistance in microbial agents relevant for human and animal health, as well as the levels of the antimicrobials which could have a growth promotion/increase yield effect. The assessment was performed for 24 antimicrobial active substances, as specified in the mandate. This scientific opinion describes the methodology used, and the main associated data gaps and uncertainties. To estimate the antimicrobial levels in the non-target feed that would not result in emergence of, and/or selection for, resistance, a model was developed. This ‘Feed Antimicrobial Resistance Selection Concentration’ (FARSC) model is based on the minimal selective concentration (MSC), or the predicted MSC (PMSC) if MSC for the most susceptible bacterial species is unavailable, the fraction of antimicrobial dose available for exposure to microorganisms in the large intestine or rumen (considering pharmacokinetic parameters), the daily faecal output or rumen volume and the daily feed intake. Currently, lack of data prevents the establishment of PMSC and/or FARSC for several antimicrobials and animal species. To address growth promotion, data from an extensive literature search were used. Specific assessments of the different substances grouped by antimicrobial classes are addressed in separate scientific opinions. General conclusions and recommendations were made. | es_ES |
dc.language | eng | es_ES |
dc.publisher | Wiley Open Access | es_ES |
dc.rights | Attribution-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nd/4.0/ | * |
dc.subject | Tecnología de los alimentos | es_ES |
dc.subject.other | Antimicrobial resistance | es_ES |
dc.subject.other | Antimicrobial resistance selection concentration (FARSC) | es_ES |
dc.subject.other | Minimal selective concentration (MSC) | es_ES |
dc.subject.other | Sub-inhibitory concentration | es_ES |
dc.subject.other | Growth promotion | es_ES |
dc.subject.other | Yield increase | es_ES |
dc.subject.other | Food-producing animals | es_ES |
dc.title | Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 1: Methodology, general data gaps and uncertainties | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.2903/J.EFSA.2021.6852 | |
dc.description.peerreviewed | SI | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 1831-4732 | |
dc.journal.title | EFSA Journal | es_ES |
dc.volume.number | 19 | es_ES |
dc.issue.number | 10 | es_ES |
dc.page.initial | 6852 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
dc.subject.unesco | 3309 Tecnología de Los Alimentos | es_ES |
dc.subject.unesco | 2414.04 Bacteriología | es_ES |
dc.description.project | The BIOHAZ Panel, leading Panel in charge of the adoption of the scientific opinion and assessment of Term of Reference 1 (ToR1, antimicrobial resistance) wishes to thank the following for the support provided to this scientific output: EFSA Panel on Animal Health and Welfare (AHAW Panel), who supported ToR1 assessments development and endorsement of those sections under their remit (animal production, main use of antimicrobials); EFSA Panel for Additives and Products or Substances used in Animal Feed (FEEDAP), in charge of the assessment and endorsement of ToR2, and providing advice and data needed for ToR1 assessments; European Medicines Agency (EMA), who was represented by an external expert and EMA secretariat as members of the Working Group (WG); Valeria Bortolaia, who was member of the WG until 17 April 2020; EFSA staff members: Angelica Amaduzzi, Gina Cioacata, Pilar Garc ıa-Vello, Michaela Hempen, Rita Navarrete, Daniel Plaza, Anita Radovnikovic and Cristiana Ventura; EMA staff members: Barbara Freischem, Zoltan Kunsagi, Nicholas Jarrett, Jordi Torren and Julia Fabrega (currently EFSA staff). The BIOHAZ Panel wishes also to acknowledge the EMA Committee for Medicinal Products for Veterinary Use (CVMP) and their experts, as well as the members of the EARS-Vet and the EURL-AR that provided data and/or information for this scientific output. | es_ES |