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dc.contributorEscuela de Ingeniería Agraria y Forestales_ES
dc.contributor.authorEscudero, Viviana
dc.contributor.authorTorres, Miguel Ángel
dc.contributor.authorDelgado, Magdalena
dc.contributor.authorSopeña Torres, Sara
dc.contributor.authorSwami, Sanjay
dc.contributor.authorMorales, Jorge
dc.contributor.authorMuñoz Barrios, Antonio
dc.contributor.authorMélida Martínez, Hugo 
dc.contributor.authorJones, Alan M.
dc.contributor.authorJordá, Lucía
dc.contributor.authorMolina, Antonio
dc.contributor.otherFisiologia Vegetales_ES
dc.date2019
dc.date.accessioned2024-05-15T07:16:12Z
dc.date.available2024-05-15T07:16:12Z
dc.identifier.citationEscudero, V., Torres, M. Á., Delgado, M., Sopeña-Torres, S., Swami, S., Morales, J., Muñoz-Barrios, A., Mélida, H., Jones, A. M., Jordá, L., & Molina, A. (2019). Mitogen-activated protein kinase phosphatase 1 (MKP1) negatively regulates the production of reactive oxygen species during Arabidopsis immune responses. Molecular Plant-Microbe Interactions, 32(4), 464-478. https://doi.org/10.1094/MPMI-08-18-0217-FIes_ES
dc.identifier.issn0894-0282
dc.identifier.urihttps://hdl.handle.net/10612/20770
dc.description.abstract[EN] Genetic ablation of the b subunit of the heterotrimeric G protein complex in agb1-2 confers defective activation of microbe-associated molecular pattern (MAMP)-triggered immunity, resulting in agb1-2 enhanced susceptibility to pathogens like the fungus Plectosphaerella cucumerina BMM. A mutant screen for suppressors of agb1-2 susceptibility (sgb) to P. cucumerina BMM identified sgb10, a new null allele (mkp1-2) of the mitogen-activated protein kinase phosphatase 1 (MKP1). The enhanced susceptibility of agb1-2 to the bacterium Pseudomonas syringae pv. tomato DC3000 and the oomycete Hyaloperonospora arabidopsidis is also abrogated by mkp1-2. MKP1 negatively balances production of reactive oxygen species (ROS) triggered by MAMPs, since ROS levels are enhanced in mkp1. The expression of RBOHD, encoding a NADPH oxidase–producing ROS, is upregulated in mkp1 upon MAMP treatment or pathogen infection. Moreover, MKP1 negatively regulates RBOHD activity, because ROS levels upon MAMP treatment are increased in mkp1 plants constitutively overexpressing RBOHD (35S::RBOHD mkp1). A significant reprograming of mkp1 metabolic profile occurs with more than 170 metabolites, including antimicrobial compounds, showing differential accumulation in comparison with wild-type plants. These results suggest that MKP1 functions downstream of the heterotrimeric G protein during MAMP-triggered immunity, directly regulating the activity of RBOHD and ROS production as well as other immune responses.es_ES
dc.languageenges_ES
dc.publisherAmerican Phytopathological Societyes_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectIngeniería agrícolaes_ES
dc.subject.otherArabidopsises_ES
dc.subject.otherArabidopsis Proteinses_ES
dc.subject.otherAscomycotaes_ES
dc.subject.otherDisease Resistancees_ES
dc.subject.otherGene Expression Regulationes_ES
dc.subject.otherProtein Tyrosine Phosphataseses_ES
dc.subject.otherPseudomonas syringaees_ES
dc.subject.otherReactive Oxygen Specieses_ES
dc.titleMitogen-Activated Protein Kinase Phosphatase 1 (MKP1) Negatively Regulates the Production of Reactive Oxygen Species During Arabidopsis Immune Responseses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.1094/MPMI-08-18-0217-FI
dc.description.peerreviewedSIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/ Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/ BIO2015-64077-R/ES/ RESPUESTAS DE INMUNIDAD REGULADAS POR EL SISTEMA DE PERCEPCION DE INTEGRIDAD DE LA PARED CELULAR VEGETALes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.essn1943-7706
dc.journal.titleMolecular Plant-Microbe Interactionses_ES
dc.volume.number32es_ES
dc.issue.number4es_ES
dc.page.initial464es_ES
dc.page.final478es_ES
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES
dc.subject.unesco3102 Ingeniería Agrícolaes_ES
dc.subject.unesco2417.19 Fisiología Vegetales_ES
dc.description.projectThis work was supported by the Secretaría de Estado de Inves-tigación, Desarrollo e Innovación grants BIO2015-64077-R and BIO2012-3291, H2020 Marie Skłodowska-Curie Actions grant (SignWALLINg-624721) from the European Union, the BRAVE Erasmus Mundi Program (European Union), and a PIF fellowship from Universidad Politécnica de Madrid. Work in the Jones lab was supported by grants from the NIGMS (R01GM065989) and National Science Foundation (MCB-0718202).es_ES


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