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dc.contributor | Escuela de Ingeniería Agraria y Forestal | es_ES |
dc.contributor.author | Escudero, Viviana | |
dc.contributor.author | Torres, Miguel Ángel | |
dc.contributor.author | Delgado, Magdalena | |
dc.contributor.author | Sopeña Torres, Sara | |
dc.contributor.author | Swami, Sanjay | |
dc.contributor.author | Morales, Jorge | |
dc.contributor.author | Muñoz Barrios, Antonio | |
dc.contributor.author | Mélida Martínez, Hugo | |
dc.contributor.author | Jones, Alan M. | |
dc.contributor.author | Jordá, Lucía | |
dc.contributor.author | Molina, Antonio | |
dc.contributor.other | Fisiologia Vegetal | es_ES |
dc.date | 2019 | |
dc.date.accessioned | 2024-05-15T07:16:12Z | |
dc.date.available | 2024-05-15T07:16:12Z | |
dc.identifier.citation | Escudero, V., Torres, M. Á., Delgado, M., Sopeña-Torres, S., Swami, S., Morales, J., Muñoz-Barrios, A., Mélida, H., Jones, A. M., Jordá, L., & Molina, A. (2019). Mitogen-activated protein kinase phosphatase 1 (MKP1) negatively regulates the production of reactive oxygen species during Arabidopsis immune responses. Molecular Plant-Microbe Interactions, 32(4), 464-478. https://doi.org/10.1094/MPMI-08-18-0217-FI | es_ES |
dc.identifier.issn | 0894-0282 | |
dc.identifier.uri | https://hdl.handle.net/10612/20770 | |
dc.description.abstract | [EN] Genetic ablation of the b subunit of the heterotrimeric G protein complex in agb1-2 confers defective activation of microbe-associated molecular pattern (MAMP)-triggered immunity, resulting in agb1-2 enhanced susceptibility to pathogens like the fungus Plectosphaerella cucumerina BMM. A mutant screen for suppressors of agb1-2 susceptibility (sgb) to P. cucumerina BMM identified sgb10, a new null allele (mkp1-2) of the mitogen-activated protein kinase phosphatase 1 (MKP1). The enhanced susceptibility of agb1-2 to the bacterium Pseudomonas syringae pv. tomato DC3000 and the oomycete Hyaloperonospora arabidopsidis is also abrogated by mkp1-2. MKP1 negatively balances production of reactive oxygen species (ROS) triggered by MAMPs, since ROS levels are enhanced in mkp1. The expression of RBOHD, encoding a NADPH oxidase–producing ROS, is upregulated in mkp1 upon MAMP treatment or pathogen infection. Moreover, MKP1 negatively regulates RBOHD activity, because ROS levels upon MAMP treatment are increased in mkp1 plants constitutively overexpressing RBOHD (35S::RBOHD mkp1). A significant reprograming of mkp1 metabolic profile occurs with more than 170 metabolites, including antimicrobial compounds, showing differential accumulation in comparison with wild-type plants. These results suggest that MKP1 functions downstream of the heterotrimeric G protein during MAMP-triggered immunity, directly regulating the activity of RBOHD and ROS production as well as other immune responses. | es_ES |
dc.language | eng | es_ES |
dc.publisher | American Phytopathological Society | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Ingeniería agrícola | es_ES |
dc.subject.other | Arabidopsis | es_ES |
dc.subject.other | Arabidopsis Proteins | es_ES |
dc.subject.other | Ascomycota | es_ES |
dc.subject.other | Disease Resistance | es_ES |
dc.subject.other | Gene Expression Regulation | es_ES |
dc.subject.other | Protein Tyrosine Phosphatases | es_ES |
dc.subject.other | Pseudomonas syringae | es_ES |
dc.subject.other | Reactive Oxygen Species | es_ES |
dc.title | Mitogen-Activated Protein Kinase Phosphatase 1 (MKP1) Negatively Regulates the Production of Reactive Oxygen Species During Arabidopsis Immune Responses | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.1094/MPMI-08-18-0217-FI | |
dc.description.peerreviewed | SI | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/ Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/ BIO2015-64077-R/ES/ RESPUESTAS DE INMUNIDAD REGULADAS POR EL SISTEMA DE PERCEPCION DE INTEGRIDAD DE LA PARED CELULAR VEGETAL | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 1943-7706 | |
dc.journal.title | Molecular Plant-Microbe Interactions | es_ES |
dc.volume.number | 32 | es_ES |
dc.issue.number | 4 | es_ES |
dc.page.initial | 464 | es_ES |
dc.page.final | 478 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
dc.subject.unesco | 3102 Ingeniería Agrícola | es_ES |
dc.subject.unesco | 2417.19 Fisiología Vegetal | es_ES |
dc.description.project | This work was supported by the Secretaría de Estado de Inves-tigación, Desarrollo e Innovación grants BIO2015-64077-R and BIO2012-3291, H2020 Marie Skłodowska-Curie Actions grant (SignWALLINg-624721) from the European Union, the BRAVE Erasmus Mundi Program (European Union), and a PIF fellowship from Universidad Politécnica de Madrid. Work in the Jones lab was supported by grants from the NIGMS (R01GM065989) and National Science Foundation (MCB-0718202). | es_ES |
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