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Título
Modulation of cytotoxic responses by targeting CD160 prolongs skin graft survival across major histocompatibility class I barrier
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Translational Research
Cita Bibliográfica
del Rio, M. L., Bravo Moral, A. M., Fernández Renedo, C., Buhler, L., Pérez Simón, J. A., Chaloin, O., Álvarez Nogal, R., Fernández Caso, M., & Rodríguez Barbosa, J.I. (2017). Modulation of cytotoxic responses by targeting CD160 prolongs skin graft survival across major histocompatibility class I barrier. Translational Research, 181, 83-95. https://doi.org/10.1016/J.TRSL.2016.09.004
Editorial
Elsevier
Fecha
2017
ISSN
1931-5244
Resumen
[EN] CD160 is a glycosylphosphatidylinositol-anchored protein of the immunoglobulin superfamily. It exhibits a pattern of expression coincident in humans and mice that is mainly restricted to cytotoxic cells and to all intestinal intraepithelial T lymphocytes. B- and T-lymphocyte attenuator (BTLA) and CD160 interact with cysteine-rich domain 1 of the extracellular region of Herpesvirus entry mediator (HVEM). CD160 engagement by HVEM can deliver inhibitory signals to a small subset of human CD4 T cells and attenuate its proliferation and cytokine secretion, but can also costimulate natural killer cells or intraepithelial lymphocytes. In turn, CD160 and BTLA can also function as agonist ligands being capable of costimulating T cells through membrane HVEM. Based on the restricted pattern of CD160 expression in cytotoxic cells, we postulated that CD160 may represent a suitable target for immune intervention in the setting of transplantation to modulate allogeneic cytotoxic responses. We demonstrated that in vivo administration of anti-CD160 antibody in combination with anti-CD40 L antibody to limit CD4 T-cell help modulated cytotoxic responses in a major histocompatibility complex class I mismatched model of allogeneic skin graft transplantation (bm1 donor to C57BL/6 recipient) and significantly prolonged graft survival. The implementation of this strategy in transplantation may reinforce current immunosuppression protocols and contribute to a better control of CD8 T-cell responses
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ID proyecto
- info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/PI13/00029/ES/Estudio de la interacción CD160/HVEM como diana para el control del rechazo mediado por linfocitos T CD8 y células NK en un biomodelo preclínico de aloreactividad//
- info:eu-repo/grantAgreement/Junta de Castilla y León/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/GRS963-A-2014/ES/Modulación terapeútica de la interacción hvem/btla en la respuesta inmune humoral alogénica en un biomodelo de trasplante//
- info:eu-repo/grantAgreement/Junta de Castilla y León//LE093U13/ES/ Estudio de las interacciones de cd160 con su receptor hvem en un modelo preclínico de aloreactividad que mimetiza la enfermedad de injerto frente a huésped en trasplante//
- info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/PI16/00002/ES/HVEM/BTLA/CD160 y PD-L1/PD1 como dianas inmunoterapéuticas en el tratamiento de tumores hematopoyéticos//
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