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Título
p73 Plays a Role in Erythroid Differentiation through GATA1 Induction
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Journal of Biological Chemistry
Número de la revista
32
Cita Bibliográfica
Marqués-García, F., Ferrandiz, N., Fernández-Alonso, R., González-Cano, L., Herreros-Villanueva, M., Rosa-Garrido, M., Fernández-García, B., Vaque, J. P., Marqués, M. M., Alonso, M. E., Segovia, J. C., León, J. and Marín, M. C. (2009). p73 plays a role in erythroid differentiation through GATA1 induction. The Journal of Biological Chemistry, 284(32), 21139-21156. https://doi.org/10.1074/jbc.M109.026849
Editorial
Elsevier
Fecha
2009
ISSN
0021-9258
Resumen
[EN] The TP73 gene gives rise to transactivation domain-p73 isoforms (TAp73) as well as ΔNp73 variants with a truncated N terminus. Although TAp73α and -β proteins are capable of inducing cell cycle arrest, apoptosis, and differentiation, ΔNp73 acts in many cell types as a dominant-negative repressor of p53 and TAp73. It has been proposed that p73 is involved in myeloid differentiation, and its altered expression is involved in leukemic degeneration. However, there is little evidence as to which p73 variants (TA or ΔN) are expressed during differentiation and whether specific p73 isoforms have the capacity to induce, or hinder, this differentiation in leukemia cells. In this study we identify GATA1 as a direct transcriptional target of TAp73α. Furthermore, TAp73α induces GATA1 activity, and it is required for erythroid differentiation. Additionally, we describe a functional cooperation between TAp73 and ΔNp73 in the context of erythroid differentiation in human myeloid cells, K562 and UT-7. Moreover, the impaired expression of GATA1 and suggests a physiological role for TP73 in erythropoiesis
Materia
Palabras clave
Peer review
SI
ID proyecto
- info:eu-repo/grantAgreement/MEC//SAF2006-10756/ES/Estudio de las interacciones funcionales de Ras y p73: implicaciones en los procesos de senescencia, diferenciación neuronal y respuesta a quimioterapia
- info:eu-repo/grantAgreement/MEC/Programa Nacional de Potenciación de Recursos Humanos del Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica 2004-2007/SAF2005-00461
- info:eu-repo/grantAgreement/MICINN/Programa Nacional de Investigación Fundamental/SAF2008-01883/ES/Biología y aplicación de la reprogramación de células hematopoyéticas al tratamiento de enfermedades hepáticas
- info:eu-repo/grantAgreement/MSC/Acción Estratégica de Salud/RD06/0020/1015/ES/Red temática de investigación cooperativa del cáncer/RETIC-RD06/0020
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