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Título
Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol
Autor
Facultad/Centro
Área de conocimiento
Cita Bibliográfica
Contraception, 2000, n. 62
Editorial
ARHP
Fecha
2000-07-10
Resumen
Dietary fibers are widely used in hypoglycaemic, hypolipidemic, slimming diets. It is probable that their ingestion coincides with the oral
administration of drugs and a modification of their pharmacokinetics can appear. In the present study, the influence of two soluble fibers
(guar gum and psyllium) was evaluated on the pharmacokinetics of ethinyloestradiol (EE) when they were administered together to female
rabbits via the oral route. Three groups of rabbits were used. All animals received 1 mg/kg of EE; this compound was administered alone
in the control group and with 3.5 g of guar gum or psyllium in the other two groups. When guar gum was administered, there was a decrease
in the extent of EE absorbed, but no change was observed in the rate of absorption. When psyllium was administered, the extent of EE
absorbed increased slightly and the rate of absorption was slower.
Materia
Palabras clave
Peer review
SI
URI
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