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dc.contributorFacultad de Veterinariaes_ES
dc.contributor.authorGarcía, Juan J.
dc.contributor.authorFernández, Nélida
dc.contributor.authorDiez, M. José
dc.contributor.authorSahagún, Ana M.
dc.contributor.authorGonzález, Aranzazu
dc.contributor.authorAlonso, M. Luisa
dc.contributor.authorPrieto, Carlos
dc.contributor.authorCalle, Ángela P.
dc.contributor.authorSierra, Matilde
dc.contributor.otherFarmacologiaes_ES
dc.date2000-07-10
dc.date.accessioned2015-07-29T12:22:42Z
dc.date.available2015-07-29T12:22:42Z
dc.date.issued2015-07-29
dc.identifier.citationContraception, 2000, n. 62es_ES
dc.identifier.urihttp://hdl.handle.net/10612/4443
dc.descriptionP. 253-257es_ES
dc.description.abstractDietary fibers are widely used in hypoglycaemic, hypolipidemic, slimming diets. It is probable that their ingestion coincides with the oral administration of drugs and a modification of their pharmacokinetics can appear. In the present study, the influence of two soluble fibers (guar gum and psyllium) was evaluated on the pharmacokinetics of ethinyloestradiol (EE) when they were administered together to female rabbits via the oral route. Three groups of rabbits were used. All animals received 1 mg/kg of EE; this compound was administered alone in the control group and with 3.5 g of guar gum or psyllium in the other two groups. When guar gum was administered, there was a decrease in the extent of EE absorbed, but no change was observed in the rate of absorption. When psyllium was administered, the extent of EE absorbed increased slightly and the rate of absorption was slower.es_ES
dc.languageenges_ES
dc.publisherARHPes_ES
dc.subjectEcología. Medio ambientees_ES
dc.subjectFarmacologíaes_ES
dc.subjectZoologíaes_ES
dc.subject.otherEthinylestradioles_ES
dc.subject.otherGuar gumes_ES
dc.subject.otherPsylliumes_ES
dc.subject.otherPharmacokineticses_ES
dc.subject.otherFiberes_ES
dc.subject.otherRabbitses_ES
dc.titleInfluence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradioles_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.peerreviewedSIes_ES


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