Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol

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Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol

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dc.contributor Facultad de Veterinaria es_ES
dc.contributor.author García, Juan J.
dc.contributor.author Fernández, Nélida
dc.contributor.author Diez, M. José
dc.contributor.author Sahagún, Ana M.
dc.contributor.author González, Aranzazu
dc.contributor.author Alonso, M. Luisa
dc.contributor.author Prieto, Carlos
dc.contributor.author Calle, Ángela P.
dc.contributor.author Sierra, Matilde
dc.contributor.other Farmacologia es_ES
dc.date 2000-07-10
dc.date.accessioned 2015-07-29T12:22:42Z
dc.date.available 2015-07-29T12:22:42Z
dc.date.issued 2015-07-29
dc.identifier.citation Contraception, 2000, n. 62 es_ES
dc.identifier.uri http://hdl.handle.net/10612/4443
dc.description P. 253-257 es_ES
dc.description.abstract Dietary fibers are widely used in hypoglycaemic, hypolipidemic, slimming diets. It is probable that their ingestion coincides with the oral administration of drugs and a modification of their pharmacokinetics can appear. In the present study, the influence of two soluble fibers (guar gum and psyllium) was evaluated on the pharmacokinetics of ethinyloestradiol (EE) when they were administered together to female rabbits via the oral route. Three groups of rabbits were used. All animals received 1 mg/kg of EE; this compound was administered alone in the control group and with 3.5 g of guar gum or psyllium in the other two groups. When guar gum was administered, there was a decrease in the extent of EE absorbed, but no change was observed in the rate of absorption. When psyllium was administered, the extent of EE absorbed increased slightly and the rate of absorption was slower. es_ES
dc.language eng es_ES
dc.publisher ARHP es_ES
dc.subject Ecología. Medio ambiente es_ES
dc.subject Farmacología es_ES
dc.subject Zoología es_ES
dc.subject.other Ethinylestradiol es_ES
dc.subject.other Guar gum es_ES
dc.subject.other Psyllium es_ES
dc.subject.other Pharmacokinetics es_ES
dc.subject.other Fiber es_ES
dc.subject.other Rabbits es_ES
dc.title Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.description.peerreviewed SI es_ES

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