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    Título
    Therapeutic effects of psyllium in type 2 diabetic patients
    Autor
    Sierra, MatildeAutoridad BuleriaORCID
    García, Juan J.
    Fernández, Nélida
    Diez, M. José
    Calle Pardo, Ángela PilarAutoridad BuleriaORCID
    Álvarez, Juan C.
    Carriedo, Demetrio
    Castro, Luis J.
    Torre, Mariano de la
    González, Aranzazu
    González, M. Angeles
    Moran, Vicente
    Prieto, Carlos
    Sahagún, Ana M.
    Facultad/Centro
    Facultad de Veterinaria
    Área de conocimiento
    Farmacologia
    Datos de la obra
    European journal of clinical nutrition, 2002, n. 56
    Editor
    Nature publishing group
    Fecha
    2002-06-24
    Abstract
    The study included three phases: phase 1 (1 week), phase 2 (treatment, 14 g fibre=day, 6 weeks) and phase 3 (4 weeks). At the end of each phase a clinical evaluation was performed after the ingestion of a test breakfast of 1824.2 kJ (436 kcal). Measurements included concentrations of blood glucose, insulin, fructosamine, GHbA1c, C-peptide and 24 h urinary glucose excretion. In addition, uric acid, cholesterol and several mineral and vitamin concentrations were also evaluated. Twenty type 2 diabetic patients (12 men and 8 women) participated in the study with a mean age of 67.4 y for men and 66 y for women. The mean body mass index of men was 28.2 kg=m2 and that of women 25.9 kg=m2. Glucose absorption decreased significantly in the presence of psyllium (12.2%); this reduction is not associated with an important change in insulin levels (5%). GHbA1c, C-peptide and 24 h urinary glucose excretion decreased (3.8, 14.9 and 22.5%, respectively) during the treatment with fibre (no significant differences) as well as fructosamine (10.9%, significant differences). Psyllium also reduced total and LDL cholesterol (7.7 and 9.2%, respectively, significant differences), and uric acid (10%, significant difference). Minerals and vitamins did not show important changes, except sodium that increased significantly after psyllium administration.
    Materia
    Ecología. Medio ambiente
    Farmacología
    Zoología
    Palabras clave
    Type 2 diabetic patients
    Ispaghula husk
    Psyllium
    Dietary fiber
    Glucose
    Insulin
    Cholesterol
    Capillary blood glucose
    Metabolic variables
    Peer review
    SI
    URI
    http://hdl.handle.net/10612/4448
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