Influence of two commercial fibers in the pharmacokinetics of ethinylestradiol in rabbits

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Influence of two commercial fibers in the pharmacokinetics of ethinylestradiol in rabbits

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dc.contributor Facultad de Veterinaria es_ES
dc.contributor.author Fernández, Nélida
dc.contributor.author Diez, M. José
dc.contributor.author Terán, M. Teresa
dc.contributor.author García, Juan J.
dc.contributor.author Calle, Ángela P.
dc.contributor.author Sierra, Matilde
dc.contributor.other Farmacologia es_ES
dc.date 1998-04-08
dc.date.accessioned 2015-07-29T12:30:49Z
dc.date.available 2015-07-29T12:30:49Z
dc.date.issued 2015-07-29
dc.identifier.citation The Journal of pharmacology and experimental therapeutics, 1998, vol. 286, n. 2 es_ES
dc.identifier.uri http://hdl.handle.net/10612/4449
dc.description P. 870-874 es_ES
dc.description.abstract Fiber formulations are used in human nutrition owing to their beneficial properties for health. It is probable that ingestion of fiber coincides with the oral administration of drugs, and a modification of its oral absorption, and therefore of its pharmacokinetics, can appear. In the present study, the compartmental and noncompartmental pharmacokinetic parameters of ethinylestradiol (EE) in rabbits after oral administration were determined. It was also studied whether the presence of two different fiber formulations [A, wheat bran (76.5%), fruit fiber (12%) and guar gum (2%) and B, Plantago ovata seeds (65%) and P. ovata seed cuticles (2.2%)] in the gastrointestinal tract modified the pharmacokinetics of EE when administered at the same time. Three groups of rabbits were used: control, fiber A and fiber B. The animals in all three groups received 1 mg/kg b. wt. EE. The estrogen was administered alone in the control group and in the presence of 4 g of fiber A and fiber B, respectively, in the other two groups. After compartmental (two-compartment open model) and noncompartmental analyses of plasma concentrations, statistical analysis revealed that the presence of fiber (both A and B) decreased between 29% and 35% the extent of EE absorbed (represented by the pharmacokinetic parameters area under the curve and the maximum plasma concentration) without affecting the rate of the absorption process (represented by the time to reach maximum concentration and the absorption rate constant). es_ES
dc.language eng es_ES
dc.publisher ASPET es_ES
dc.subject Ecología. Medio ambiente es_ES
dc.subject Farmacología es_ES
dc.subject Zoología es_ES
dc.subject.other Commercial fibers es_ES
dc.subject.other Pharmacokinetics es_ES
dc.subject.other Ethinylestradiol es_ES
dc.subject.other Rabbits es_ES
dc.subject.other Ratones es_ES
dc.title Influence of two commercial fibers in the pharmacokinetics of ethinylestradiol in rabbits es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.description.peerreviewed SI es_ES

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