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dc.contributorFacultad de Veterinariaes_ES
dc.contributor.authorFernández, Nélida
dc.contributor.authorDiez, M. José
dc.contributor.authorTerán, M. Teresa
dc.contributor.authorGarcía, Juan J.
dc.contributor.authorCalle, Ángela P.
dc.contributor.authorSierra, Matilde
dc.contributor.otherFarmacologiaes_ES
dc.date1998-04-08
dc.date.accessioned2015-07-29T12:30:49Z
dc.date.available2015-07-29T12:30:49Z
dc.date.issued2015-07-29
dc.identifier.citationThe Journal of pharmacology and experimental therapeutics, 1998, vol. 286, n. 2es_ES
dc.identifier.urihttp://hdl.handle.net/10612/4449
dc.descriptionP. 870-874es_ES
dc.description.abstractFiber formulations are used in human nutrition owing to their beneficial properties for health. It is probable that ingestion of fiber coincides with the oral administration of drugs, and a modification of its oral absorption, and therefore of its pharmacokinetics, can appear. In the present study, the compartmental and noncompartmental pharmacokinetic parameters of ethinylestradiol (EE) in rabbits after oral administration were determined. It was also studied whether the presence of two different fiber formulations [A, wheat bran (76.5%), fruit fiber (12%) and guar gum (2%) and B, Plantago ovata seeds (65%) and P. ovata seed cuticles (2.2%)] in the gastrointestinal tract modified the pharmacokinetics of EE when administered at the same time. Three groups of rabbits were used: control, fiber A and fiber B. The animals in all three groups received 1 mg/kg b. wt. EE. The estrogen was administered alone in the control group and in the presence of 4 g of fiber A and fiber B, respectively, in the other two groups. After compartmental (two-compartment open model) and noncompartmental analyses of plasma concentrations, statistical analysis revealed that the presence of fiber (both A and B) decreased between 29% and 35% the extent of EE absorbed (represented by the pharmacokinetic parameters area under the curve and the maximum plasma concentration) without affecting the rate of the absorption process (represented by the time to reach maximum concentration and the absorption rate constant).es_ES
dc.languageenges_ES
dc.publisherASPETes_ES
dc.subjectEcología. Medio ambientees_ES
dc.subjectFarmacologíaes_ES
dc.subjectZoologíaes_ES
dc.subject.otherCommercial fiberses_ES
dc.subject.otherPharmacokineticses_ES
dc.subject.otherEthinylestradioles_ES
dc.subject.otherRabbitses_ES
dc.subject.otherRatoneses_ES
dc.titleInfluence of two commercial fibers in the pharmacokinetics of ethinylestradiol in rabbitses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.peerreviewedSIes_ES


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