Effects of slowed gastrointestinal motility on levodopa pharmacokinetics

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Effects of slowed gastrointestinal motility on levodopa pharmacokinetics

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dc.contributor Facultad de Veterinaria es_ES
dc.contributor.author Fernández, Nélida
dc.contributor.author García, Juan J.
dc.contributor.author Diez, M. José
dc.contributor.author Sahagún, Ana M.
dc.contributor.author González, Aranzazu
dc.contributor.author Diez, Raquel
dc.contributor.author Sierra, Matilde
dc.contributor.other Farmacologia es_ES
dc.date 2010-03-23
dc.date.accessioned 2015-07-29T12:31:13Z
dc.date.available 2015-07-29T12:31:13Z
dc.date.issued 2015-07-29
dc.identifier.citation Autonomic Neuroscience: Basic and Clinical, 2010, n. 156 es_ES
dc.identifier.uri http://hdl.handle.net/10612/4450
dc.description P. 67-72 es_ES
dc.description.abstract Autonomic disorders are often seen in Parkinson's disease, with disturbances of the gastrointestinal tract occurring most frequently. These disorders, mainly a delay in gastric emptying and slowed gastrointestinal motility, can modify the pharmacokinetics and effectiveness of drugs used to treat Parkinson's disease and administered orally. In this study, we evaluated in a rabbit model the pharmacokinetics of levodopa (administered with carbidopa) in the context of gastrointestinal motility slowed by the administration of an anticholinergic drug. Levodopa+carbidopa (20:5 mg/kg) and the anticholinergic biperiden (100 μg/kg) were orally administered to rabbits over one of two time periods (7 or 14 days) to verify the stabilization of levodopa concentrations. The values of the area under the curve (AUC) and Cmax were higher on the final day of treatment with an increase in AUC of 25% on day 7 and 33.4% on day 14; for Cmax, the increase was 15% on day 7 and 12.8% on day 14. The values of AUC and Cmax were lower than those obtained when levodopa was administered to rabbits with normal gastrointestinal motility. The values obtained for Cmin (baseline sample obtained before administration) also increased with treatment duration (24% and 47.4% on days 7 and 14, respectively). These values were higher than those obtained in the absence of anticholinergic administration. We conclude that, under our experimental conditions of slowed gastrointestinal motility, levodopa absorption diminishes, and final concentrations and Cmin are higher than under conditions of normal motility. es_ES
dc.language eng es_ES
dc.publisher Elsevier es_ES
dc.subject Ecología. Medio ambiente es_ES
dc.subject Farmacología es_ES
dc.subject Zoología es_ES
dc.subject.other Biperiden es_ES
dc.subject.other Levodopa es_ES
dc.subject.other Pharmacokinetics es_ES
dc.subject.other Rabbits es_ES
dc.subject.other Slowed gastrointestinal motility es_ES
dc.subject.other Farmacogenética es_ES
dc.subject.other Ratones es_ES
dc.title Effects of slowed gastrointestinal motility on levodopa pharmacokinetics es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.description.peerreviewed SI es_ES

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