Compartir
Título
The hydrosoluble fiber Plantago ovata husk improves levodopa (with carbidopa) bioavailability after repeated administration
Autor
Facultad/Centro
Área de conocimiento
Datos de la obra
Journal of the neurological , 2008, n. 271
Editor
Elsevier
Fecha
2008-05-12
Abstract
The influence of treatment duration (7 or 14 days) with Plantago ovata husk/levodopa/carbidopa in the bioavailability and other
pharmacokinetic parameters of levodopa were evaluated in rabbits. Fiber was administered at two different doses, 100 and 400 mg/kg, and
the dosage of levodopa/carbidopa was 20:5 mg/kg. These doses were administered once a day. When 100 mg/kg of fiber was administered,
the mean AUC value obtained for levodopa increased 20.2% from day 1 to day 7, and 27.2% from day 1 to day 14; Cmax was 8.6% higher on
day 7 and 11.7% higher on day 14. When administering 400 mg/kg of fiber, the increase in AUC values was 17.6% on day 7 and 24.9% on
day 14, and that of Cmax 11.1% on day 7 and 11.3% on day 14. The concentration determined immediately before drug administration (Cmin)
increased progressively with the duration of treatment, and the highest increase (53.2%) was observed on day 14 with 100 mg/kg of fiber.
There was also a delay in levodopa elimination (higher MRT and lower Cl) in a fiber-dose dependent manner. In summary, we found that
there was an improvement in the extent of levodopa absorbed with higher final concentrations and that levodopa elimination was slower with
the administration of P. ovata husk.
Materia
Palabras clave
Peer review
SI
URI
Collections
- Untitled [4589]
Files in this item
Tamaño:
160.2
xmlui.dri2xhtml.METS-1.0.size-kilobytes
Formato:
Adobe PDF