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dc.contributorFacultad de Veterinariaes_ES
dc.contributor.authorDiez, M. José
dc.contributor.authorGarcía, Juan J.
dc.contributor.authorPrieto, Carlos
dc.contributor.authorFernández, Nélida
dc.contributor.authorSahagún, Ana M.
dc.contributor.authorSierra, Matilde
dc.contributor.otherFarmacologiaes_ES
dc.date2008-05-12
dc.date.accessioned2015-07-31T10:23:43Z
dc.date.available2015-07-31T10:23:43Z
dc.date.issued2015-07-31
dc.identifier.citationJournal of the neurological , 2008, n. 271es_ES
dc.identifier.urihttp://hdl.handle.net/10612/4472
dc.descriptionP. 15-20es_ES
dc.description.abstractThe influence of treatment duration (7 or 14 days) with Plantago ovata husk/levodopa/carbidopa in the bioavailability and other pharmacokinetic parameters of levodopa were evaluated in rabbits. Fiber was administered at two different doses, 100 and 400 mg/kg, and the dosage of levodopa/carbidopa was 20:5 mg/kg. These doses were administered once a day. When 100 mg/kg of fiber was administered, the mean AUC value obtained for levodopa increased 20.2% from day 1 to day 7, and 27.2% from day 1 to day 14; Cmax was 8.6% higher on day 7 and 11.7% higher on day 14. When administering 400 mg/kg of fiber, the increase in AUC values was 17.6% on day 7 and 24.9% on day 14, and that of Cmax 11.1% on day 7 and 11.3% on day 14. The concentration determined immediately before drug administration (Cmin) increased progressively with the duration of treatment, and the highest increase (53.2%) was observed on day 14 with 100 mg/kg of fiber. There was also a delay in levodopa elimination (higher MRT and lower Cl) in a fiber-dose dependent manner. In summary, we found that there was an improvement in the extent of levodopa absorbed with higher final concentrations and that levodopa elimination was slower with the administration of P. ovata husk.es_ES
dc.languageenges_ES
dc.publisherElsevieres_ES
dc.subjectEcología. Medio ambientees_ES
dc.subjectFarmacologíaes_ES
dc.subjectZoologíaes_ES
dc.subject.otherLevodopa bioavailabilityes_ES
dc.subject.otherCarbidopaes_ES
dc.subject.otherPlantago ovata huskes_ES
dc.subject.otherPharmacokineticses_ES
dc.subject.otherRabbitses_ES
dc.subject.otherRatoneses_ES
dc.titleThe hydrosoluble fiber Plantago ovata husk improves levodopa (with carbidopa) bioavailability after repeated administrationes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.peerreviewedSIes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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