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    Título
    Effect of glucomannan and the dosage form on ethinylestradiol oral absorption in rabbits
    Autor
    González, Aranzazu
    Fernández, Nélida
    Sahagún, Ana M.
    García, Juan J.
    Diez, M. José
    Castro, Luis J.
    Sierra, Matilde
    Facultad/Centro
    Facultad de Veterinaria
    Área de conocimiento
    Farmacologia
    Datos de la obra
    Contraception, 2004, n. 70
    Editor
    ARHP
    Fecha
    2004-07-10
    Descripción física
    P. 423-427
    Abstract
    To the beneficial properties of dietary fiber in human health, several disadvantages can be added as the possible modification of the bioavailability of other drugs when administered by the oral route. In this study, the influence of glucomannan in the oral bioavailability of ethinyl estradiol (EE), when administered to female rabbits in two different dosage forms (enteric capsules and dispersed in water), was established. To carry out the study, three groups of six animals each were used. All animals received 1 mg kg 1 oral EE, and rabbits in groups 2 and 3 received 1.5 g glucomannan dispersed in water or in enteric capsules, respectively, immediately before EE. When comparing the results obtained after the administration of EE/glucomannan dispersed in water with those obtained after the administration of this estrogen without fiber, we can see that Cmax is 1.4 times lower, AUC 1.9 times lower and that tmax is identical (10 min). However, after the administration of fiber in enteric capsules, AUC and Cmax are higher (4.1 and 7.8 times, respectively) than when the estrogen was administered alone, and also, there is a delay in tmax (20 min). After the administration of glucomannan in the enteric capsule, the fiber forms, as in the stomach, a highly viscous solution in the gut that would limit EE access to the mucosal surface delaying its absorption. However, this effect could be compensated by a reduction of EE metabolism in the intestinal wall, leading to a higher absorption of the estrogen.
    Materia
    Ecología. Medio ambiente
    Farmacología
    Zoología
    Palabras clave
    Ethinyl estradiol
    Glucomannan
    Rabbits
    Fiber
    Pharmacokinetics
    Oral absorption
    Ratones
    Idioma
    eng
    Tipo documental
    info:eu-repo/semantics/article
    Peer review
    SI
    URI
    http://hdl.handle.net/10612/4476
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    • Artículos de revista (post-print) [1543]
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