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dc.contributorFacultad de Veterinariaes_ES
dc.contributor.authorFernández, Nélida
dc.contributor.authorGarcía, Juan J.
dc.contributor.authorSierra, Matilde
dc.contributor.authorDiez, M. José
dc.contributor.authorTerán, M. Teresa
dc.contributor.otherFarmacologiaes_ES
dc.date1998-06-15
dc.date.accessioned2015-08-19T11:51:17Z
dc.date.available2015-08-19T11:51:17Z
dc.date.issued2015-08-19
dc.identifier.citationNew Zealand Veterinary Journal, 1998,n.46es_ES
dc.identifier.urihttp://hdl.handle.net/10612/4529
dc.descriptionP. 173-176es_ES
dc.description.abstractAims. To determine the bioavailability of levamisole in sheep. Methods. Levamisole was administered to three groups of six Merino sheep orally and intramuscularly at three dose levels of 5, 7.5 and 1O mg/kg. There was a washout period of 1 week between treatments. Blood samples were collected by jugular venepuncture and plasma was separated immediately by centrifugation and stored at - 20 ºC until analysed.The levamisole concentration in plasma was determined by high performance liquid chromatography with a u.v. detection method. Individual plasma levamisole concentration-time data were analysed using the compartmental method. Results. The values obtained for ka , Cmax , tmax and F show a moderate rate and extent of absorption after oral administration of levamisole while, after intramuscular administration, these values demonstrate a high rate and extent of absorption of levamisole. The intramuscular bioavailability was higher than the oral bioavailability (rate of absorption three-fold faster, extent of absorption 2.5 -33% higher and Cmax.. two-fold higher). The Friedman test involving dose and route of administration showed that the route of administration affects ka, Cmax' tmax and F; significant differences were found in these parameters. Clinical relevance. On the basis of these data, the recommended routes for the administration of levamisole in sheep are oral for gastro-intestinal nematodiasis and intramuscular for extragastric nematodiasis.es_ES
dc.languageenges_ES
dc.publisherTaylor and Francises_ES
dc.subjectEcología. Medio ambientees_ES
dc.subjectFarmacologíaes_ES
dc.subjectZoologíaes_ES
dc.subject.otherLevamisolees_ES
dc.subject.otherBioavailabilityes_ES
dc.subject.otherSheepes_ES
dc.titleBioavailability of levamisole after intramuscular and oral administration in sheepes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.peerreviewedSIes_ES


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