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dc.contributorFacultad de Veterinariaes_ES
dc.contributor.authorGarcía, Juan J.
dc.contributor.authorDiez, M. José
dc.contributor.authorSierra, Matilde
dc.contributor.authorTerán, M. Teresa
dc.contributor.otherFarmacologiaes_ES
dc.date1994-02-09
dc.date.accessioned2015-08-19T11:51:31Z
dc.date.available2015-08-19T11:51:31Z
dc.date.issued2015-08-19
dc.identifier.citationJournal of Veterinary Pharmacology and Therapeutics, 1994, n. 17es_ES
dc.identifier.urihttp://hdl.handle.net/10612/4530
dc.descriptionP. 135-140es_ES
dc.description.abstractThe bioavailability of levamisole in rabbits was determined after subcutaneous and oral administration at three dose levels of 12.5, 16.0 and 20.0 mg/kg. After non-compartmental analysis the mean values obtained were: Cmax = 3.54, 4.51 and 5.39 µg/ml; tmax = 12.0, 22.0 and 20.0 min; F = 134.8, 105.4 and 124.1% after subcutaneous administration for each dose, respectively, and Cmax = 0.71, 1.32 and 1.77 µg/ml; tmax = 46.0, 96.0 and 84.0 min; F = 53.0, 62.0 and 80.7% after oral administration. The extent and rate of absorption from the two routes differed sign.ificantly, except for tmax at the 12.5 mg/kg dose. After compartmental analysis the pharmacokinetics of levamisole was characteristic of a two-compartment open model in 13 rabbits and of a one-compartment open model in two rabbits after subcutaneous administration, while it was two compartmental in nine and one compartmental in six rabbits after oral admini­ stration. The kª values were 0.321, 0.145 and 0.145 min-1 after subcutaneous adininistration and 0.054, 0.023 and 0.027 min- 1 after oral administration. There were no significant differences between the values of Cmax• tmax and AUC calculated by compartmental and non-compartmental analysis.es_ES
dc.languageenges_ES
dc.publisherBlackwell Scientific Publicationses_ES
dc.subjectEcología. Medio ambientees_ES
dc.subjectFarmacologíaes_ES
dc.subjectZoologíaes_ES
dc.subject.otherBioavailabilityes_ES
dc.subject.otherLevamisolees_ES
dc.subject.otherOral routeses_ES
dc.subject.otherSubcutaneouses_ES
dc.titleBioavailability of levamisole administered by subcutaneous and oral routes in rabbitses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.peerreviewedSIes_ES


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