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dc.contributorFacultad de Veterinariaes_ES
dc.contributor.authorGonzález, Aranzazu
dc.contributor.authorSahagún, Ana M.
dc.contributor.authorDiez, M. José
dc.contributor.authorFernández, Nélida
dc.contributor.authorSierra, Matilde
dc.contributor.authorGarcía, Juan J.
dc.contributor.otherFarmacologiaes_ES
dc.date2007-06-30
dc.date.accessioned2015-08-19T11:52:58Z
dc.date.available2015-08-19T11:52:58Z
dc.date.issued2015-08-19
dc.identifier.citationAmerican journal research, 2007, n. 68es_ES
dc.identifier.urihttp://hdl.handle.net/10612/4532
dc.descriptionP. 101-106es_ES
dc.description.abstractObjective-To evaluate bioavailability and other pharmacokinetic variables of a commercial formulation of ivermectin after IV administration to sheep. Animals-6 healthy adult sheep. Procedures-A single dose of a commercial formulation of ivermectin (200 µg/kg) was administered IV to each sheep. After a washout period of 3 weeks, each sheep was administered ivermectin by Se injection. Plasma samples were obtained for up to 36 and up to 42 days after IV and se administration, respectively. lvermectin concentrations were quantified by use of high-performance liquid chromatography with fluorescence detection. Results-Results obtained indicated that after IV administration, ivermectin is cleared slowly from plasma, tends to distribute and accumulate in the peripheral compartment, and is slowly eliminated from the body. After se administration, noncompartmental analysis revealed that bioavailability of ivermectin is nearly complete (98.20%), has a slow mean absorption time of 0.96 days, and reaches a maximum plasma concentration of 19.55 ng/ ml at 3.13 days. Conclusions and Clinical Relevance-The commercial formulation of ivermectin used in this study can be administered se to sheep on the basis of a nearly complete bioavailability. Inaddition, the maximum plasma concentration and interval from se injection until maximum plasma concentration is obtained are higher than those reported by other authors who used other routes of administration.es_ES
dc.languageenges_ES
dc.publisherAmerican Veterinary Medical Assn.es_ES
dc.subjectEcología. Medio ambientees_ES
dc.subjectFarmacologíaes_ES
dc.subjectZoologíaes_ES
dc.subject.otherBioavailabilityes_ES
dc.subject.otherCommercial formulationes_ES
dc.subject.otherIvermectines_ES
dc.subject.otherSheepes_ES
dc.titleBioavailability of a commercial formulation of ivermectin after subcutaneous administration to sheepes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.peerreviewedSIes_ES


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