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dc.contributorFacultad de Veterinariaes_ES
dc.contributor.authorGarcía, Juan J.
dc.contributor.authorFernández, Nélida
dc.contributor.authorCalle, Ángela P.
dc.contributor.authorDiez, M. José
dc.contributor.authorSahagún, Ana M.
dc.contributor.authorSierra, Matilde
dc.contributor.otherFarmacologiaes_ES
dc.date2009-04-17
dc.date.accessioned2015-09-03T11:35:52Z
dc.date.available2015-09-03T11:35:52Z
dc.date.issued2015-09-03
dc.identifier.citationDrug metabolism and disposition, 2009, vol. 37, n. 7es_ES
dc.identifier.urihttp://hdl.handle.net/10612/4542
dc.descriptionP. 1434-1442es_ES
dc.description.abstractGastrointestinal dysfunction is common in Parkinson’s disease. Fiber therapy could be used to reduce the symptoms of gastrointestinal motility disorders. In a previous study, we showed that slowed gastrointestinal motility modified levodopa pharmacokinetics: area under the plasma concentration-time curve (AUC) and maximum plasma concentration (Cmax) decreased and the elimination was delayed. In this study, we evaluated whether or not the hydrosoluble fiber Plantago ovata husk is useful in improving levodopa pharmacokinetics in rabbits with autonomic gastrointestinal disorders induced by the administration of the anticholinergic biperiden. Levodopa carbidopa (20:5 mg/kg), biperiden (100 g/ kg), and P. ovata husk (at two different doses: 100 and 400 mg/kg) were administered orally to rabbits for two periods of time (7 or 14 days). In all groups of animals, the AUC values were approximately 50% higher on the final day of treatment than on day 1. Cmax was also higher, with the greater increase at the 400 mg/kg dose of fiber, which resulted in a boost of approximately 35%. On day 1 of treatment and with both doses of fiber, AUC values were very similar to those obtained in previous work in rabbits with normal gastrointestinal motility, but the Cmax was lower. However, after 7 or 14 days, the AUC values were higher, but Cmax remained lower. The greatest differences were observed in plasma concentration before drug administration (Cmin), for which the highest increase was obtained with the dose of 400 mg/kg fiber on day 14 of treatment (349.8%). P. ovata husk could be beneficial in patients with Parkinson’s disease because it regulates stool transit in the intestine and because it improves levodopa pharmacokinetics when gastrointestinal peristalsis is slowed. These changes could lead to a possible delay in the onset of dyskinesias and to changes in prognosis.es_ES
dc.languageenges_ES
dc.publisherAmerican Society for Pharmacology and Experimental Therapeuticses_ES
dc.subjectEcología. Medio ambientees_ES
dc.subjectFarmacologíaes_ES
dc.subjectToxicologíaes_ES
dc.subjectZoologíaes_ES
dc.subject.otherPlantago ovata huskes_ES
dc.subject.otherLevodopaes_ES
dc.subject.otherGastrointestinal disorderses_ES
dc.subject.otherRabbitses_ES
dc.titleEffects of Plantago ovata Husk on Levodopa (with Carbidopa) Bioavailability in Rabbits with Autonomic Gastrointestinal Disorderses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.peerreviewedSIes_ES


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