Effects of dietary factors on levodopa pharmacokinetics

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Effects of dietary factors on levodopa pharmacokinetics

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Title: Effects of dietary factors on levodopa pharmacokinetics
Author: Fernández, Nélida;García, Juan J.;Diez, M. José;Sahagún, Ana M.;Diez, Raquel;Sierra, Matilde
xmlui.dri2xhtml.METS-1.0.item-contributor: Facultad de Veterinaria
xmlui.dri2xhtml.METS-1.0.item-area: Farmacologia
Abstract: lmportance of the fíeld: Levodopa is the most effective treatment for Parkinson's disease, so it is important to understand the pharmacokinetic an d pharmacodynamic features of this drug. Considering the pharmaco­ kinetics of levodopa and the factors that can modify it are essential for the clinician when prescribing levodopa products in order to maximize their therapeutic effects. · Areas covered in thís review: This pa per reviews the studies carried out eva luating the interaction between levodopa and dietary factors. What the reader will gain: The reader will gain a greater understanding of the different dietary factors that can affect levodopa pharmacokinetics and, thus, the therapeutic response that is obtained with this drug in several situations. Take home message: An understanding of the pharmacokinetics of any drug is crucial for the establishment of its optima! therapeutic regimen, but this assumes a special importance with levodopa, due to its extensive presystemic rnetabolism, rapid absorption in the proximal small intestine and short plasma ha lf-life. Major problems with levodopa treatment are the fluctuations in clin­ ical response experienced in patients with advanced Parkinson's disease that sometimes are related to the peripheral pharmacokinetics of levodopa. Stu­ dies of levodopa interactions are very important to improve patient response to this drug.
xmlui.dri2xhtml.METS-1.0.item-desfisica: P. 633-642
xmlui.dri2xhtml.METS-1.0.item-peerreviewed: SI
Publisher: Ashley Publications
xmlui.dri2xhtml.METS-1.0.item-citation: Expert opinion on drug metabolism and toxicology, 2010, n. 6
URI: http://hdl.handle.net/10612/4552
Date: 2010-07-15
xmlui.dri2xhtml.METS-1.0.item-tipo: info:eu-repo/semantics/article
Subject: Farmacología
Medicina. Salud
xmlui.dri2xhtml.METS-1.0.item-palclave: Dietary factors
Interaction
Levodopa
Pharmacokinetics
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