Effects of dietary factors on levodopa pharmacokinetics
Área de conocimiento
Datos de la obra
Expert opinion on drug metabolism and toxicology, 2010, n. 6
lmportance of the fíeld: Levodopa is the most effective treatment for Parkinson's disease, so it is important to understand the pharmacokinetic an d pharmacodynamic features of this drug. Considering the pharmaco kinetics of levodopa and the factors that can modify it are essential for the clinician when prescribing levodopa products in order to maximize their therapeutic effects. · Areas covered in thís review: This pa per reviews the studies carried out eva luating the interaction between levodopa and dietary factors. What the reader will gain: The reader will gain a greater understanding of the different dietary factors that can affect levodopa pharmacokinetics and, thus, the therapeutic response that is obtained with this drug in several situations. Take home message: An understanding of the pharmacokinetics of any drug is crucial for the establishment of its optima! therapeutic regimen, but this assumes a special importance with levodopa, due to its extensive presystemic rnetabolism, rapid absorption in the proximal small intestine and short plasma ha lf-life. Major problems with levodopa treatment are the fluctuations in clin ical response experienced in patients with advanced Parkinson's disease that sometimes are related to the peripheral pharmacokinetics of levodopa. Stu dies of levodopa interactions are very important to improve patient response to this drug.