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    Título
    Effects of dietary factors on levodopa pharmacokinetics
    Autor
    Fernández, Nélida
    García, Juan J.
    Diez, M. José
    Sahagún, Ana M.
    Diez, Raquel
    Sierra, MatildeAutor de la institución ORCID
    Facultad/Centro
    Facultad de Veterinaria
    Área de conocimiento
    Farmacologia
    Datos de la obra
    Expert opinion on drug metabolism and toxicology, 2010, n. 6
    Editor
    Ashley Publications
    Fecha
    2010-07-15
    Descripción física
    P. 633-642
    Résumé
    lmportance of the fíeld: Levodopa is the most effective treatment for Parkinson's disease, so it is important to understand the pharmacokinetic an d pharmacodynamic features of this drug. Considering the pharmaco­ kinetics of levodopa and the factors that can modify it are essential for the clinician when prescribing levodopa products in order to maximize their therapeutic effects. · Areas covered in thís review: This pa per reviews the studies carried out eva luating the interaction between levodopa and dietary factors. What the reader will gain: The reader will gain a greater understanding of the different dietary factors that can affect levodopa pharmacokinetics and, thus, the therapeutic response that is obtained with this drug in several situations. Take home message: An understanding of the pharmacokinetics of any drug is crucial for the establishment of its optima! therapeutic regimen, but this assumes a special importance with levodopa, due to its extensive presystemic rnetabolism, rapid absorption in the proximal small intestine and short plasma ha lf-life. Major problems with levodopa treatment are the fluctuations in clin­ ical response experienced in patients with advanced Parkinson's disease that sometimes are related to the peripheral pharmacokinetics of levodopa. Stu­ dies of levodopa interactions are very important to improve patient response to this drug.
    Materia
    Farmacología
    Medicina. Salud
    Palabras clave
    Dietary factors
    Interaction
    Levodopa
    Pharmacokinetics
    Idioma
    eng
    Tipo documental
    info:eu-repo/semantics/article
    Peer review
    SI
    URI
    http://hdl.handle.net/10612/4552
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