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dc.contributorFacultad de Veterinariaes_ES
dc.contributor.authorFernández, Nélida
dc.contributor.authorGarcía, Juan J.
dc.contributor.authorDiez, M. José
dc.contributor.authorSahagún, Ana M.
dc.contributor.authorDiez, Raquel
dc.contributor.authorSierra, Matilde 
dc.contributor.otherFarmacologiaes_ES
dc.date2010-07-15
dc.date.accessioned2015-09-03T13:34:10Z
dc.date.available2015-09-03T13:34:10Z
dc.date.issued2015-09-03
dc.identifier.citationExpert opinion on drug metabolism and toxicology, 2010, n. 6es_ES
dc.identifier.urihttp://hdl.handle.net/10612/4552
dc.descriptionP. 633-642es_ES
dc.description.abstractlmportance of the fíeld: Levodopa is the most effective treatment for Parkinson's disease, so it is important to understand the pharmacokinetic an d pharmacodynamic features of this drug. Considering the pharmaco­ kinetics of levodopa and the factors that can modify it are essential for the clinician when prescribing levodopa products in order to maximize their therapeutic effects. · Areas covered in thís review: This pa per reviews the studies carried out eva luating the interaction between levodopa and dietary factors. What the reader will gain: The reader will gain a greater understanding of the different dietary factors that can affect levodopa pharmacokinetics and, thus, the therapeutic response that is obtained with this drug in several situations. Take home message: An understanding of the pharmacokinetics of any drug is crucial for the establishment of its optima! therapeutic regimen, but this assumes a special importance with levodopa, due to its extensive presystemic rnetabolism, rapid absorption in the proximal small intestine and short plasma ha lf-life. Major problems with levodopa treatment are the fluctuations in clin­ ical response experienced in patients with advanced Parkinson's disease that sometimes are related to the peripheral pharmacokinetics of levodopa. Stu­ dies of levodopa interactions are very important to improve patient response to this drug.es_ES
dc.languageenges_ES
dc.publisherAshley Publicationses_ES
dc.subjectFarmacologíaes_ES
dc.subjectMedicina. Saludes_ES
dc.subject.otherDietary factorses_ES
dc.subject.otherInteractiones_ES
dc.subject.otherLevodopaes_ES
dc.subject.otherPharmacokineticses_ES
dc.titleEffects of dietary factors on levodopa pharmacokineticses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.peerreviewedSIes_ES


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