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dc.contributorFacultad de Veterinariaes_ES
dc.contributor.authorVillanueva, Irma
dc.contributor.authorDiez, M. José
dc.contributor.authorGarcía, Juan J.
dc.contributor.authorFernández, Nélida
dc.contributor.authorSahagún, Ana M.
dc.contributor.authorSierra, Ana
dc.contributor.authorSierra, Matilde
dc.contributor.otherFarmacologiaes_ES
dc.date2003-04-03
dc.date.accessioned2015-09-03T13:35:02Z
dc.date.available2015-09-03T13:35:02Z
dc.date.issued2015-09-03
dc.identifier.citationAmerican journal of veterinary research, 2003, vol. 64, n. 10es_ES
dc.identifier.urihttp://hdl.handle.net/10612/4554
dc.descriptionP. 1283-1287es_ES
dc.description.abstractTo evaluate the contribution of first-pass hepatic metabolism of levamisole on levamisole disposition in rabbits. 30 male New Zealand white rabbits. Rabbits were randomly place into 2 groups. Rabbits in the first group received levamisole via the marginal ear vein at the following 3 doses: 12.5, 16, and 20mg/Kg (5 rabbits for each dose). Rabbits of the second group received levamisole via the jejunal vein at the same doses (5 rabbits each). During the following 240 minute period, plasma samples were obtained and quantified for levamisole concentrations by reversed-phase high-performace liquid chromatography. No significant differences were found between pharmacokinetic parameters calculated by compartmental or noncompartmental analysis. Mean hepoatic extraction ratio ranged from 0.044 to 0.017 and from 0.020 to 0.081 when area under the plasma concentration-time curve values were obtained after compartmental or noncompartmental analysis, respectively. After compartmental analysis, plasma concentration decreased bi-exponentially. Mean pharmacokinetic parameter values were as follows for each dose ( 12.5, 16, and 20 mg/Kg, respectively): after levamisole administration via the marginal ear vein, volume of distribution at steady state (Vss)= 4.26, 4.33, and 3.20 L/Kg; total body clearance (Cl) = 49.04,43.77 and 39.26 mL/Kg*min; and half-life associated with β-phase (t,1/2β)= 77.93, 85.39, and 69.79 minutes. After levamisole administration vea the jejunal vein, Vss = 4.38, 2.85, and 2.97 L/Kg, Cl= 48.14, 42.40, and 39.69 mL/Kg*min; and t1/2b = 101.9, 76.71, and 76.13 minutes. Levamisole has a low degree of hepatic extraction in rabbitses_ES
dc.languageenges_ES
dc.publisherAmerican Veterinary Medical Assn.es_ES
dc.subjectFarmacologíaes_ES
dc.subjectZoologíaes_ES
dc.subject.otherLevamisoles_ES
dc.subject.otherPharmacokineticses_ES
dc.subject.otherHepatic metabolismes_ES
dc.subject.otherRabbitses_ES
dc.titleEffect of first-pass hepatic metabolism on the disposition of levamisole after intravenous administration in rabbitses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.peerreviewedSIes_ES


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