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dc.contributor | Facultad de Veterinaria | es_ES |
dc.contributor.author | Castro, Luis J. | |
dc.contributor.author | Sahagún , Ana M. | |
dc.contributor.author | Diez Liébana, María José | |
dc.contributor.author | Fernández, Nélida | |
dc.contributor.author | Sierra Vega, Matilde | |
dc.contributor.author | García, Juan J. | |
dc.contributor.other | Farmacologia | es_ES |
dc.date | 2009-02-01 | |
dc.date.accessioned | 2015-09-04T11:40:03Z | |
dc.date.available | 2015-09-04T11:40:03Z | |
dc.date.issued | 2015-09-04 | |
dc.identifier.citation | The Veterinary Journal, 2009, n. 180 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10612/4571 | |
dc.description | P. 389-395 | es_ES |
dc.description.abstract | The pharmacokinetics of doxycycline were investigated in sheep after oral (PO) and intravenous (IV) administration. The IV data were best described using a 2- (n = 5) or 3- (n = 6) compartmental open model. Mean pharmacokinetic parameters obtained using a 2-compartmental model included a volume of distribution at steady-state (Vss) of 1.759 ± 0.3149 L/kg, a total clearance (Cl) of 3.045 ± 0.5264 mL/ kg/min and an elimination half-life (t1/2b) of 7.027 ± 1.128 h. Comparative values obtained from the 3-compartmental mean values were: Vss of 1.801 ± 0.3429 L/kg, a Cl of 2.634 ± 0.6376 mL/kg/min and a t1/2b of 12.11 ± 2.060 h. Mean residence time (MRT0_1) was 11.18 ± 3.152 h. After PO administration, the data were best described by a 2-compartment open model. The pharmacokinetic parameter mean values were: maximum plasma concentration (Cmax), 2.130 ± 0.950 lg/mL; time to reach Cmax (tmax), 3.595 ± 3.348 h, and absorption half-life (t1=2k01 ), 36.28 ± 14.57 h. Non-compartmental parameter values were: Cmax, 2.182 ± 0.9117 lg/mL; tmax, 3.432 ± 3.307 h; F, 35.77 ± 10.20%, and mean absorption time (MAT0–∞), 25.55 ± 15.27 h. These results suggest that PO administration of doxycycline could be useful as an antimicrobial drug in sheep. | es_ES |
dc.language | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.subject | Farmacología | es_ES |
dc.subject | Veterinaria | es_ES |
dc.subject | Zoología | es_ES |
dc.subject.other | Pharmacokinetics | es_ES |
dc.subject.other | Dosycycline | es_ES |
dc.subject.other | Sheep | es_ES |
dc.subject.other | Intravenous | es_ES |
dc.subject.other | Oral | es_ES |
dc.title | Pharmacokinetics of doxycycline in sheep after intravenous and oral administration | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.peerreviewed | SI | es_ES |
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