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    Título
    Pharmacokinetics of levamisole in rabbits after intravenous administration
    Autor
    García, Juan J.
    Diez, M. José
    Sierra, MatildeAutoridad BuleriaORCID
    Terán, M. TeresaAutoridad Buleria
    Facultad/Centro
    Facultad de Veterinaria
    Área de conocimiento
    Farmacologia
    Datos de la obra
    Journal of Veterinary Pharmacology and Therapeutics, 1992, n. 15
    Editor
    Wiley-Blackwell
    Fecha
    1992-01-08
    Abstract
    A compartmental and non-compartmental pharmacokinetic study was carried out on rabbits after intravenous (i.v.) administration of levamisole al the three dose rales: 12.5. 16.0 and 20.0 mg/kg body weight. Using compartmental analysis, the disposition of levamisole best fitted a t wo-compartmental open model with mean values of α= 0.1278, 0. 1019 and 0.1282 mi n - 1 ; β =0.0139 O.O 126 and 0.0124 min- 1 ; A = 6 .24. 5.27 and 10.58 µg/ml and β = 2.14. :3083 and 5.08 µg/ml for each dose, respectively. The statistical moment theory was mainly used for non-compartmental analysis. Values for mean residence time (MRT) of 69.2, 71 .7 and 73. 1 min were obtained for each dose. The mean values for volume of dist ribution at steady state ( Vd(ss)). determined by compartmental analysis, were 3879. 3 279 and 2735 ml/kg for each dose. and values obtained using the statistical moment theory were :3760. 3015 and 2943 ml/kg; there were no statistically significant differences using Student's paired 1-lest. Identical conclusions were obtained using both methods when the parameters β. AUC and Cl were compared.
    Materia
    Ecología. Medio ambiente
    Farmacología
    Veterinaria
    Palabras clave
    Pharmacokinetics
    Levamisole
    Intravenous administration
    Rabbits
    Peer review
    SI
    URI
    http://hdl.handle.net/10612/4576
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    Nombre:
    Journal of Veterinary Pharmacology and Therapeutics, 1992, p. 85-90
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