Pharmacokinetics of levamisole in rabbits after intravenous administration

Abstract

A compartmental and non-compartmental pharmacokinetic study was carried out on rabbits after intravenous (i.v.) administration of levamisole al the three dose rales: 12.5. 16.0 and 20.0 mg/kg body weight. Using compartmental analysis, the disposition of levamisole best fitted a t wo-compartmental open model with mean values of α= 0.1278, 0. 1019 and 0.1282 mi n - 1 ; β =0.0139 O.O 126 and 0.0124 min- 1 ; A = 6 .24. 5.27 and 10.58 µg/ml and β = 2.14. :3083 and 5.08 µg/ml for each dose, respectively. The statistical moment theory was mainly used for non-compartmental analysis. Values for mean residence time (MRT) of 69.2, 71 .7 and 73. 1 min were obtained for each dose. The mean values for volume of dist ribution at steady state ( Vd(ss)). determined by compartmental analysis, were 3879. 3 279 and 2735 ml/kg for each dose. and values obtained using the statistical moment theory were :3760. 3015 and 2943 ml/kg; there were no statistically significant differences using Student's paired 1-lest. Identical conclusions were obtained using both methods when the parameters β. AUC and Cl were compared.