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dc.contributorFacultad de Veterinariaes_ES
dc.contributor.authorGarcía, Juan J.
dc.contributor.authorDiez Liébana, María José 
dc.contributor.authorSierra Vega, Matilde 
dc.contributor.authorTerán Somaza, María Teresa 
dc.contributor.otherFarmacologiaes_ES
dc.date1992-01-08
dc.date.accessioned2015-09-04T11:41:32Z
dc.date.available2015-09-04T11:41:32Z
dc.date.issued2015-09-04
dc.identifier.citationJournal of Veterinary Pharmacology and Therapeutics, 1992, n. 15es_ES
dc.identifier.urihttp://hdl.handle.net/10612/4576
dc.descriptionP. 85-90es_ES
dc.description.abstractA compartmental and non-compartmental pharmacokinetic study was carried out on rabbits after intravenous (i.v.) administration of levamisole al the three dose rales: 12.5. 16.0 and 20.0 mg/kg body weight. Using compartmental analysis, the disposition of levamisole best fitted a t wo-compartmental open model with mean values of α= 0.1278, 0. 1019 and 0.1282 mi n - 1 ; β =0.0139 O.O 126 and 0.0124 min- 1 ; A = 6 .24. 5.27 and 10.58 µg/ml and β = 2.14. :3083 and 5.08 µg/ml for each dose, respectively. The statistical moment theory was mainly used for non-compartmental analysis. Values for mean residence time (MRT) of 69.2, 71 .7 and 73. 1 min were obtained for each dose. The mean values for volume of dist ribution at steady state ( Vd(ss)). determined by compartmental analysis, were 3879. 3 279 and 2735 ml/kg for each dose. and values obtained using the statistical moment theory were :3760. 3015 and 2943 ml/kg; there were no statistically significant differences using Student's paired 1-lest. Identical conclusions were obtained using both methods when the parameters β. AUC and Cl were compared.es_ES
dc.languageenges_ES
dc.publisherWiley-Blackwelles_ES
dc.subjectEcología. Medio ambientees_ES
dc.subjectFarmacologíaes_ES
dc.subjectVeterinariaes_ES
dc.subject.otherPharmacokineticses_ES
dc.subject.otherLevamisolees_ES
dc.subject.otherIntravenous administrationes_ES
dc.subject.otherRabbitses_ES
dc.titlePharmacokinetics of levamisole in rabbits after intravenous administrationes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.peerreviewedSIes_ES


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