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dc.contributorFacultad de Veterinariaes_ES
dc.contributor.authorFernández, Nélida
dc.contributor.authorSierra, Matilde 
dc.contributor.authorDiez, M. José
dc.contributor.authorTerán, M. Teresa 
dc.contributor.authorSahagún, Ana M.
dc.contributor.authorGarcía, Juan J.
dc.contributor.otherFarmacologiaes_ES
dc.date1996-09-25
dc.date.accessioned2015-09-04T11:43:27Z
dc.date.available2015-09-04T11:43:27Z
dc.date.issued2015-09-04
dc.identifier.citationContraception, 1996, n.53es_ES
dc.identifier.urihttp://hdl.handle.net/10612/4577
dc.descriptionP. 307-312es_ES
dc.description.abstractThe pharmacokinetics of ethinyloestradiol (EE 2) after intravenous administration of 30,50 and 100 µg.kg-1 was investigated in rabbits. A high-performance liquid chromatographic (HPLC) method with electrochemical (EC) detection was used to measure EE2 in plasma samples in order to avoid the interferences of natural oestrogens. After compartmental analysis, the disposition of EE2 was well described by a two-cpmpartmental open model with mean values of: α = 0.3448 ± 0.2922, 0.1965 ± 0.1755, 0.3058 ± 0.1225 m-1 and β = 0.0137 ± 0.0018, 0.0140 ± 0.0065, 0.0198 ± 0.0066 min-1, for the three doses studied, respectively. There were no dose-related differences (ANOVA, P< 0.05) in a,b or Vss but significant differences were detected in clearance (90.9 ± 18.7; 80.6 ± 17.6; 116.3 ± 21.5 ml.min-1.Kg-1) between the 100 µg.kg-1 group and lower dose groups. The AUC increased significantly with the doses ( 341.7 ± 67.1; 645.8 ± 143.9; 892.2 ± 211.9 ng.min.ml-1). After non-compartmental analysis there were no significant differences in λ, MRT or Vss as a function of dose, but these differences were significant differences in AUC or CI values obtained by compartmental and non-compartmental analysis.es_ES
dc.languageenges_ES
dc.publisherElsevieres_ES
dc.subjectEcología. Medio ambientees_ES
dc.subjectFarmacologíaes_ES
dc.subjectVeterinariaes_ES
dc.subject.otherEthinylestradioles_ES
dc.subject.otherPharmacokineticses_ES
dc.subject.otherItravenous administrationes_ES
dc.subject.otherRabbitses_ES
dc.subject.otherOestrogenses_ES
dc.titlePharmacokinetics of ethinyloestradiol in rabbits after intravenous administrationes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.peerreviewedSIes_ES


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