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dc.contributorFacultad de Veterinariaes_ES
dc.contributor.authorFernández, Nélida
dc.contributor.authorHernandez, Luis
dc.contributor.authorSierra, Matilde 
dc.contributor.authorDiez, M. José
dc.contributor.authorCalle Pardo, Ángela Pilar 
dc.contributor.authorCarriedo, Demetrio
dc.contributor.authorSahagún, Ana M.
dc.contributor.authorAnguera, Anna
dc.contributor.authorGarcía, Juan J.
dc.contributor.otherFarmacologiaes_ES
dc.date2014-03-14
dc.date.accessioned2015-10-21T14:18:03Z
dc.date.available2015-10-21T14:18:03Z
dc.date.issued2015-10-21
dc.identifier.citationBMC complementary and alternative medicine, 2014, n. 14es_ES
dc.identifier.urihttp://hdl.handle.net/10612/4705
dc.descriptionP. 296-305es_ES
dc.description.abstractBackground: Plantago ovata husk therapy could be used in patients with Parkinson disease to reduce the symptoms of gastrointestinal disorders, but it is important to know whether this compound modifies levodopa pharmacokinetics. The maintenance of constant plasma concentrations of levodopa abolishes the clinical fluctuations in parkinsonian patients. The aim of this randomised clinical trial was to establish the influence of the fiber Plantago ovata husk in the pharmacokinetics of levodopa when administered to Parkinson patients well controlled by their oral medication. Methods: To evaluate the effects of this fiber on several biochemical parameters. 18 volunteers participated in the study and received alternatively two treatments (Plantago ovata husk or placebo) with their usual levodopa/carbidopa oral dose. On days 0 (initial situation), 14 and 35 of the study, blood samples were taken to assess levodopa pharmacokinetics and to determine biochemical parameters. Results: Levodopa Cmax was very similar in the initial situation (603.2 ng/ml) and after placebo administration (612.0 ng/ml), being slightly lower (547.8 ng/ml) when Plantago ovata husk was given. AUC was very similar in the three groups: initial situation.- 62.87 μg.min/ml, fiber treatment.- 64.47 μg.min/ml and placebo treatment.- 65.10 μg.min/ml. Fiber reduced significantly the number of peaks observed in the levodopa concentrations, maintaining concentrations more stable. No significant differences were found in total cholesterol, LDL-cholesterol and triglycerides with the administration of Plantago ovata husk. Conclusions: Plantago ovata husk administration caused a smoothing and homogenization of levodopa absorption, providing more stable concentrations and final higher levels, resulting in a great benefit for patients.es_ES
dc.languageenges_ES
dc.publisherBiomed centrales_ES
dc.subjectEcología. Medio ambientees_ES
dc.subjectFarmacologíaes_ES
dc.subjectMedicina. Saludes_ES
dc.subject.otherLevodopaes_ES
dc.subject.otherParkinson patientses_ES
dc.subject.otherPharmacokineticses_ES
dc.subject.otherBiochemical parameterses_ES
dc.subject.otherPlantago ovata huskes_ES
dc.titleA randomised clinical trial to evaluate the effects of Plantago ovata husk in Parkinson patients: changes in levodopa pharmacokinetics and biochemical parameterses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.peerreviewedSIes_ES


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