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    Título
    Systemic and mammary gland disposition of enrofloxacin in healthy sheep following intramammary administration
    Autor
    López, Cristina
    García, Juan J.
    Sierra, MatildeAutoridad BuleriaORCID
    Diez, M. José
    Pérez
    Sahagún, Ana M.
    Fernández, Nélida
    Facultad/Centro
    Facultad de Veterinaria
    Área de conocimiento
    Farmacologia
    Datos de la obra
    BMC veterinary research, 2015, n. 11
    Editor
    Biomed central
    Fecha
    2015-05-15
    Abstract
    Background: Mastitis is one of the most important diseases affecting dairy sheep. Antimicrobial drugs are often administered directly through teat to treat or prevent this disease, but data on drug distribution within glandular tissue are scarce and it cannot be estimated from concentrations in milk. Thus, the aim of this study was to investigate systemic and mammary gland distribution of enrofloxacin after intramammary administration. The drug was administered to 6 healthy lactating Assaf sheep with an injector containing an enrofloxacin preparation (1 g drug/5 g ointment). Blood samples were collected at 0, 30, 60, 90, 120, 150 and 180 min. Animals were then sedated and sacrificed, and glandular tissue samples were obtained from treated udders at 2, 4, 6 and 8 cm height. Enrofloxacin concentrations were measured in plasma and tissue samples by UV high-performed liquid chromatography. Results: Mean enrofloxacin plasma concentrations were below 0.5 μg/mL. Mean tissue concentrations decreased in mammary gland with vertical distance from the teat, ranging from 356.6 μg/g at 2 cm to 95.60 μg/g at the base of the udder. Glandular tissue concentrations best fitted to a decreasing monoexponential model, and showed a good correlation with an ex vivo model previously developed. Conclusions: Enrofloxacin concentrations were effective in the entire glandular tissue against the main pathogens causing mastitis in sheep. These results suggest that this drug may be suitable to treat mastitis in sheep by intramammary administration.
    Materia
    Farmacología
    Sanidad animal
    Veterinaria
    Zoología
    Palabras clave
    Enrofloxacin
    Sheep
    Intramammary
    Systemic
    Glandular tissue
    Disposition
    Peer review
    SI
    URI
    http://hdl.handle.net/10612/4706
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    BMC veterinary research, 2015, p. 88-94
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