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    Título
    Detection and replication of QTL underlying resistance to gastrointestinal nematodes in adult sheep using the ovine 50K SNP array
    Autor
    Atlija, Marina
    Arranz Santos, Juan JoséAutor de la institución
    Martínez Valladares, MaríaAutor de la instituciónORCID
    Gutiérrez Gil, BeatrizAutor de la institución
    Facultad/Centro
    Facultad de Veterinaria
    Área de conocimiento
    Producción Animal
    Datos de la obra
    Genetics Selection Evolution, 2016, vol. 48, n. 4
    Editor
    Institut National de la Recherche Agronomique (INRA)
    Fecha
    2016-01-15
    Abstract
    Persistence of gastrointestinal nematode (GIN) infection and the related control methods have major impacts on the sheep industry worldwide. Based on the information generated with the Illumina OvineSNP50 BeadChip (50 K chip), this study aims at confirming quantitative trait loci (QTL) that were previously identified by microsatellite ‑ based genome scans and identifying new QTL and allelic variants that are associated with indicator traits of parasite resistance in adult sheep. We used a commercial half ‑ sib population of 518 Spanish Churra ewes with available data for fecal egg counts (FEC) and serum levels of immunoglobulin A (IgA) to perform different genome scan QTL mapping analyses based on classical linkage analysis (LA), a combined linkage disequilibrium and linkage analysis (LDLA) and a genome ‑ wide association study (GWAS)
    Materia
    Producción animal
    Palabras clave
    • Nematodos
    • Ganado ovino
    • Gastrointestinal nematodes
    Patrocinador
    This work was supported by a competitive grant from the Castilla and León regional government (Junta de Castilla y León) (Ref. LE245A12-2) and the AGL2012-34437 project funded by the Spanish Ministry of Economy and Competitiveness (MINECO). M Atlija is a grateful grantee of a Marie Curie fellowship funded by the EC-funded Initial Training Network (ITN) NematodeSystemHealth (FP7-PEOPLE-2010-ITN Ref. 264639). B Gutiérrez-Gil is funded through the Spanish “Ramón y Cajal” Programme (RYC-2012-10230) from the MINECO.
    Peer review
    SI
    ID proyecto
    • info:eu-repo/grantAgreement/EC/FP7/264639
    URI
    http://hdl.handle.net/10612/5017
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