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dc.contributorInstituto Universitario de Biomedicina (IBIOMED)es_ES
dc.contributor.authorPisonero-Vaquero, Sandra
dc.contributor.authorGonzález Gallego, Javier 
dc.contributor.authorSánchez-Campos, Sonia
dc.contributor.authorGarcía Mediavilla, María Victoria 
dc.contributor.otherOtroses_ES
dc.date2015-07-11
dc.date.accessioned2016-12-19T16:29:47Z
dc.date.available2016-12-19T16:29:47Z
dc.date.issued2016-12-19
dc.identifier.citationCurrent Medicinal Chemistry, 2015, 22es_ES
dc.identifier.urihttp://hdl.handle.net/10612/5685
dc.descriptionP. 2991-3012es_ES
dc.description.abstractNon-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome, is one of the most common chronic liver diseases, which may progress to fibrosis, cirrhosis and hepatocellular carcinoma. NAFLD is characterized by the accumulation of lipids in the liver arising from multiple factors: increased fatty acid uptake, increased de novo lipogenesis, reduced fatty acid oxidation and very low density lipoproteins (VLDL) secretion. Most therapeutic approaches for this disease are often directed at reducing body mass index and improving insulin resistance through lifestyle modifications, bariatric surgery and pharmacological treatments. Nevertheless, there is increasing evidence that the use of natural compounds, as polyphenols, exert multiple benefits on the disorders associated with NAFLD. These molecules seem to be able to regulate the expression of genes mainly involved in de novo lipogenesis and fatty acid oxidation, which contributes to their lipid-lowering effect in the liver. Their antioxidant, anti-inflammatory, antifibrogenic and antilipogenic properties seem to confer on them a great potential as strategy for preventing NAFLD progression. In this review, we summarized the effects of these compounds, especially flavonoids, and their mechanisms of action, that have been reported in several studies carried out in in vitro and in vivo models of NAFLDes_ES
dc.languageenges_ES
dc.publisherBentham Science Publisherses_ES
dc.subjectMedicina. Saludes_ES
dc.subject.otherNon-alcoholic fatty liver disease (NAFLD)es_ES
dc.subject.otherAntioxidantes_ES
dc.subject.otherFlavonoidses_ES
dc.subject.otherInsulin resistancees_ES
dc.titleFlavonoids and Related Compounds in Non-Alcoholic Fatty Liver Disease Therapyes_ES
dc.typeinfo:eu-repo/semantics/preprintes_ES


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