Placental thrombosis in acute phase abortions during experimental Toxoplasma gondii infection in sheep

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Placental thrombosis in acute phase abortions during experimental Toxoplasma gondii infection in sheep

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dc.contributor Facultad de Veterinaria es_ES
dc.contributor.author Castaño, P
dc.contributor.author Fuertes, M
dc.contributor.author Ferre, I
dc.contributor.author Fernández, M
dc.contributor.author Ferreras, MC
dc.contributor.author Moreno-Gonzalo, J
dc.contributor.author González-Lanza, C
dc.contributor.author Katzer, F
dc.contributor.author Regidor-Cerrillo, J
dc.contributor.author Ortega-Mora, LM
dc.contributor.author Pérez, V
dc.contributor.author Benavides, J
dc.contributor.other Sanidad Animal es_ES
dc.date 2014
dc.date.accessioned 2016-12-23T14:21:24Z
dc.date.available 2016-12-23T14:21:24Z
dc.date.issued 2016-12-23
dc.identifier.citation Veterinary Research, 2014, 29, 45 es_ES
dc.identifier.uri http://hdl.handle.net/10612/5693
dc.description 43 p. es_ES
dc.description.abstract After oral administration of ewes during mid gestation with 2000 freshly prepared sporulated oocysts of T. gondii isolate M4, abortions occurred between days 7 and 11 in 91.6% of pregnant and infected ewes. Afterwards, a further infection was carried out at late gestation in another group of sheep with 500 sporulated oocysts. Abortions happened again between days 9 and 11 post infection (pi) in 58.3% of the infected ewes. Classically, abortions in natural and experimental ovine toxoplasmosis usually occur one month after infection. Few experimental studies have reported the so-called acute phase abortions as early as 7 to 14 days after oral inoculation of oocysts, and pyrexia was proposed to be responsible for abortion, although the underline mechanism was not elucidated. In the present study, all placentas analysed from ewes suffering acute phase abortions showed infarcts and thrombosis in the caruncullar villi of the placentomes and ischemic lesions (periventricular leukomalacia) in the brain of some foetuses. The parasite was identified by PCR in samples from some placentomes of only one sheep, and no antigen was detected by immunohistochemical labelling. These findings suggest that the vascular lesions found in the placenta, and the consequent hypoxic damage to the foetus, could be associated to the occurrence of acute phase abortions. Although the pathogenesis of these lesions remains to be determined, the infectious dose or virulence of the isolate may play a role in their development es_ES
dc.language eng es_ES
dc.subject Veterinaria es_ES
dc.title Placental thrombosis in acute phase abortions during experimental Toxoplasma gondii infection in sheep es_ES
dc.type info:eu-repo/semantics/article es_ES
dc.description.peerreviewed SI es_ES
dc.rights.accessRights info:eu-repo/semantics/openAccess es_ES

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