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dc.contributorFacultad de Veterinariaes_ES
dc.contributor.authorCastaño, P
dc.contributor.authorFuertes, M
dc.contributor.authorFerre, I
dc.contributor.authorFernández, M
dc.contributor.authorFerreras, MC
dc.contributor.authorMoreno-Gonzalo, J
dc.contributor.authorGonzález-Lanza, C
dc.contributor.authorKatzer, F
dc.contributor.authorRegidor-Cerrillo, J
dc.contributor.authorOrtega-Mora, LM
dc.contributor.authorPérez, V
dc.contributor.authorBenavides, J
dc.contributor.otherSanidad Animales_ES
dc.date2014
dc.date.accessioned2016-12-23T14:21:24Z
dc.date.available2016-12-23T14:21:24Z
dc.date.issued2016-12-23
dc.identifier.citationVeterinary Research, 2014, 29, 45es_ES
dc.identifier.urihttp://hdl.handle.net/10612/5693
dc.description43 p.es_ES
dc.description.abstractAfter oral administration of ewes during mid gestation with 2000 freshly prepared sporulated oocysts of T. gondii isolate M4, abortions occurred between days 7 and 11 in 91.6% of pregnant and infected ewes. Afterwards, a further infection was carried out at late gestation in another group of sheep with 500 sporulated oocysts. Abortions happened again between days 9 and 11 post infection (pi) in 58.3% of the infected ewes. Classically, abortions in natural and experimental ovine toxoplasmosis usually occur one month after infection. Few experimental studies have reported the so-called acute phase abortions as early as 7 to 14 days after oral inoculation of oocysts, and pyrexia was proposed to be responsible for abortion, although the underline mechanism was not elucidated. In the present study, all placentas analysed from ewes suffering acute phase abortions showed infarcts and thrombosis in the caruncullar villi of the placentomes and ischemic lesions (periventricular leukomalacia) in the brain of some foetuses. The parasite was identified by PCR in samples from some placentomes of only one sheep, and no antigen was detected by immunohistochemical labelling. These findings suggest that the vascular lesions found in the placenta, and the consequent hypoxic damage to the foetus, could be associated to the occurrence of acute phase abortions. Although the pathogenesis of these lesions remains to be determined, the infectious dose or virulence of the isolate may play a role in their developmentes_ES
dc.languageenges_ES
dc.subjectVeterinariaes_ES
dc.titlePlacental thrombosis in acute phase abortions during experimental Toxoplasma gondii infection in sheepes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.peerreviewedSIes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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