• español
  • English
  • français
  • Deutsch
  • português (Brasil)
  • italiano
Consorcio BUCLE Recolector
  • Contact Us
  • Send Feedback
  • Enlaces y accesos
    • Derechos de autor
    • Políticas
    • Guía de autoarchivo
    • FAQ y ayuda
    • La ULE y el Acceso Abierto
    • español
    • English
    • français
    • Deutsch
    • português (Brasil)
    • italiano
    • español
    • English
    • français
    • Deutsch
    • português (Brasil)
    • italiano
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Repositorio
    Institucional
    Abierto

    Consorcio BUCLE Recolector

    Browse

    All of BULERIACommunities and CollectionsAuthorsDirectoresTitlesSubjectsFacultad/CentroÁrea de conocimientoFecha de creación/publicaciónTitulaciónThis CollectionAuthorsDirectoresTitlesSubjectsFacultad/CentroÁrea de conocimientoFecha de creación/publicaciónTitulación

    My Account

    Login

    Statistics

    View Usage Statistics

    Otros enlaces

    View Item 
    •   BULERIA Home
    • Scientific Production
    • Untitled
    • View Item
    •   BULERIA Home
    • Scientific Production
    • Untitled
    • View Item

    Compartir

    Export

    RISMendeleyRefworksZotero
    • edm
    • marc
    • xoai
    • qdc
    • ore
    • ese
    • dim
    • uketd_dc
    • oai_dc
    • etdms
    • rdf
    • mods
    • mets
    • didl
    • premis

    Citas

    Título
    Development and Characterization of Protective Haemophilus parasuis Subunit Vaccines Based on Native Proteins with Affinity to Porcine Transferrin and Comparison with Other Subunit and Commercial Vaccines
    Autor
    Frandoloso, Rafael
    Martínez Martínez, SoniaAutoridad BuleriaORCID
    Rodríguez Ferri, Elías FernandoAutoridad BuleriaORCID
    García-Iglesias, María-José
    Pérez Martínez, ClaudiaAutoridad BuleriaORCID
    Martínez-Fernández, Beatriz
    Gutiérrez Martín, César BernardoAutoridad BuleriaORCID
    Facultad/Centro
    Facultad de Veterinaria
    Área de conocimiento
    Sanidad Animal
    Datos de la obra
    Clinical and Vaccine Immunology, January 2011, vol. 18, n. 1
    Editor
    American Society for Microbiology
    Fecha
    2011-01-08
    Abstract
    Haemophilus parasuis is the agent responsible for causing Glasser’s disease, which is characterized by fibrinous polyserositis, polyarthritis, and meningitis in pigs. In this study, we have characterized native outer membrane proteins with affinity to porcine transferrin (NPAPT) from H. parasuis serovar 5, Nagasaki strain. This pool of proteins was used as antigen to developed two vaccine formulations: one was adjuvanted with a mineral oil (Montanide IMS 2215 VG PR), while the other was potentiated with a bacterial neuraminidase from Clostridium perfringens. The potential protective effect conferred by these two vaccines was compared to that afforded by two other vaccines, consisting of recombinant transferrin-binding protein (rTbp) A or B fragments from H. parasuis, Nagasaki strain, and by a commercially available inactivated vaccine. Five groups of colostrum-deprived piglets immunized with the vaccines described above, one group per each vaccine, and a group of nonvaccinated control animals were challenged intratracheally with a lethal dose (3 108 CFU) of H. parasuis, Nagasaki strain. The two vaccines containing rTbps yielded similar results with minimal protection against death, clinical signs, gross and microscopic lesions, and H. parasuis invasion. In contrast, the two vaccines composed of NPAPT antigen and commercial bacterin resulted in a strong protection against challenge (without deaths and clinical signs), mild histopathological changes, and no recovery of H. parasuis, thus suggesting their effectiveness in preventing Glasser’s disease outbreaks caused by serovar 5
    Materia
    Sanidad animal
    Palabras clave
    Haemophilus parasuis
    Commercial Vaccines
    Subunit Vaccines
    Ganado porcino
    Peer review
    SI
    URI
    http://hdl.handle.net/10612/6460
    Collections
    • Untitled [2807]
    Show full item record
    Files in this item
    Nombre:
    CLINICAL AND VACCINE IMMUNOLOGY.pdf
    Tamaño:
    1.620 xmlui.dri2xhtml.METS-1.0.size-megabytes
    Formato:
    Adobe PDF
    Thumbnail
    FilesOpen