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dc.contributorFacultad de Veterinariaes_ES
dc.contributor.authorMartínez Martínez, Sonia 
dc.contributor.authorFrandoloso, Rafael
dc.contributor.authorGutiérrez Martín, César Bernardo 
dc.contributor.authorLampreave, Fermín
dc.contributor.authorGarcía-Iglesias, María-José
dc.contributor.authorPérez-Martínez, Claudia
dc.contributor.authorRodríguez Ferri, Elías Fernando 
dc.contributor.otherSanidad Animales_ES
dc.date2011-11-23
dc.date.accessioned2017-08-01T22:39:10Z
dc.date.available2017-08-01T22:39:10Z
dc.date.issued2017-08-02
dc.identifier.citationVeterinary Immunology and Immunopathology, 2011es_ES
dc.identifier.urihttp://hdl.handle.net/10612/6471
dc.description8 p.es_ES
dc.description.abstractHaemophilus parasuis is the etiological agent of Glässer’s disease, which is characterized by fibrinous polyserositis, polyarthritis and meningitis in pigs. This study was focused on the characterization of the acute-phase response after immunization and infection of colostrum-deprived pigs with H. parasuis serovar 5, by measuring serum concentrations of three positive acute-phase proteins (APPs) (pig major acute-phase protein pig, MAP; haptoglobin, HPG; C-reactive protein, CRP) and one negative APP (apolipoprotein A-I, ApoA-I). Six experimental groups were established: a non-immunized but infected control group (CTL); two groups immunized with either a recombinant transferrin-binding protein (Tbp) A or TbpB fragment from H. parasuis Nagasaki strain (rTbpA and rTbpB, respectively); two groups immunized with native outer membrane proteins with affinity to porcine transferrin (NPAPT), one of them inoculated intramuscularly (NPAPTim) and the other intratracheally (NPAPTit), and the last group receiving a commercially available bacterin (PG). The greatest concentrations of the three positive APPs and the lowest concentration of the negative APP were detected in CTL group, as well as in those animals belonging to rTbpA or rTbpB groups that died in response to challenge. Significant differences (P < 0.005) were found in these groups when comparing challenge with the following days after it. However, no significant differences were seen for the remaining vaccinated groups (NPAPTim, NPAPTit and PG), which were effectively protected against Glässer’s disease. Therefore, APPs could be used as useful biomarkers for both evaluating disease progression and determining vaccination effectivenesses_ES
dc.languageenges_ES
dc.publisherElsevieres_ES
dc.subjectSanidad animales_ES
dc.subjectVeterinariaes_ES
dc.subject.otherAcute-phase proteinses_ES
dc.subject.otherHaemophilus parasuises_ES
dc.subject.otherGlässer’s diseasees_ES
dc.titleAcute phase protein concentrations in colostrum-deprived pigs immunized with subunit and commercial vaccines against Glässer’s diseasees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.peerreviewedSIes_ES


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