The Breast Cancer Resistance Protein (BCRP/ABCG2) influences the levels of enterolignans and their metabolites in plasma, milk and mammary gland

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The Breast Cancer Resistance Protein (BCRP/ABCG2) influences the levels of enterolignans and their metabolites in plasma, milk and mammary gland

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Title: The Breast Cancer Resistance Protein (BCRP/ABCG2) influences the levels of enterolignans and their metabolites in plasma, milk and mammary gland
Author: García Mateos, Dafne;García-Villalba, Rocío;Marañón, José Ángel;Espín, Juan Carlos;Merino Peláez, Gracia;Álvarez de Felipe, Ana Isabel
xmlui.dri2xhtml.METS-1.0.item-contributor: Facultad de Veterinaria
xmlui.dri2xhtml.METS-1.0.item-area: Fisiologia
Abstract: Lignans are phytoestrogens widely used in dietary supplements and functional foods. After oral ingestion, these polyphenols are metabolized to enterolignans, the main gut microbiota-derived metabolites with weak estrogenic/anti-estrogenic activities. The ABCG2 transporter is highly expressed in the mammary gland and could be responsible for enterolignan accumulation. We aimed here at evaluating the levels of enterolignans and their conjugates in plasma, milk and mammary tissue from wild-type and knockout Abcg2-/- female mice after a lignan-enriched diet for one week. In vitro transepithelial transport of enterolignans was also assayed with ABCG2- transduced cells. Enterolactone and enterodiol levels were higher in plasma and lower in milk from Abcg2-/- compared with wild-type mice. Both enterolactone and enterodiol were accumulated in the mammary gland but with significant differences only for enterolactone. Our results suggest that ABCG2 may be determinant for plasma and milk levels of enterolignans whose accumulation could exert chemopreventive effects against breast cancer
xmlui.dri2xhtml.METS-1.0.item-desfisica: P. 648-654
xmlui.dri2xhtml.METS-1.0.item-peerreviewed: SI
Publisher: Elsevier
xmlui.dri2xhtml.METS-1.0.item-citation: Journal of Functional Foods, 2017, n. 35
URI: http://hdl.handle.net/10612/6863
Date: 2017
xmlui.dri2xhtml.METS-1.0.item-tipo: info:eu-repo/semantics/article
Subject: Sanidad animal
Veterinaria
xmlui.dri2xhtml.METS-1.0.item-palclave: Enterolactone
Enterodiol
ABCG2,
Milk
Mammary gland
Gut microbiota
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