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    Título
    The Breast Cancer Resistance Protein (BCRP/ABCG2) as a key player in the tissue distribution of flaxseed lignans and their metabolites
    Autor
    García Mateos, Dafne
    García-Villalba, Rocío
    Otero, Jon Andoni
    Marañón, José Ángel
    Espín, Juan Carlos
    Álvarez de Felipe, Ana IsabelAutoridad BuleriaORCID
    Merino Peláez, GraciaAutoridad BuleriaORCID
    Facultad/Centro
    Facultad de Veterinaria
    Área de conocimiento
    Fisiologia
    Datos de la obra
    Food & Function
    Editor
    Royal Society of Chemistry
    Fecha
    2018-01-15
    Abstract
    Lignans are dietary polyphenols, which are metabolized by the gut microbiota into the phytoestrogenic metabolites enterolignans, mainly enterolactone and enterodiol. The Breast Cancer Resistance Protein (BCRP/ABCG2) is an efflux transporter that affects plasma and milk secretion of several drugs and natural compounds. We hypothesized here that Abcg2 could influence levels of lignans and their derived metabolites in target tissues. Consequently, we aimed to evaluate the role of Abcg2 in the tissue distribution of these compounds. We used Abcg2-/- knockout and wild-type male mice fed with a lignanenriched diet for one week and analysed plasma, small intestine, colon, liver, kidneys and testicles. High levels of lignans as well as enterolignans and their glucuronide and sulfate conjugates in the small intestine and colon were detected, with higher concentrations of the conjugates in the wild-type compared with Abcg2-/- mice. Particularly relevant was the detection of 24-fold and 8-fold higher concentrations of enterolactone-sulfate and enterolactone-glucuronide, respectively, in the kidney of Abcg2-/- compared with wild-type mice. In conclusion, our study showed that lignans and their derived metabolites were in vivo substrates of Abcg2, which affected their plasma and tissue levels. These results highlight the role of Abcg2 in influencing the health-beneficial properties of dietary lignans
    Materia
    Fisiología
    Palabras clave
    Cáncer
    BCRP/ABCG2
    Proteínas
    URI
    http://hdl.handle.net/10612/8801
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