2024-03-28T23:46:43Zhttp://buleria.unileon.es/oai/requestoai:buleria.unileon.es:10612/45302020-12-10T09:00:57Zcom_10612_17col_10612_18
Facultad de Veterinaria
García, Juan J.
Diez, M. José
Sierra, Matilde
Terán, M. Teresa
Farmacologia
1994-02-09
2015-08-19T11:51:31Z
2015-08-19T11:51:31Z
2015-08-19
Journal of Veterinary Pharmacology and Therapeutics, 1994, n. 17
http://hdl.handle.net/10612/4530
P. 135-140
The bioavailability of levamisole in rabbits was determined after subcutaneous and oral administration at three dose levels of 12.5, 16.0 and 20.0 mg/kg.
After non-compartmental analysis the mean values obtained were: Cmax = 3.54, 4.51 and 5.39 µg/ml; tmax = 12.0, 22.0 and 20.0 min; F = 134.8, 105.4 and
124.1% after subcutaneous administration for each dose, respectively, and Cmax
= 0.71, 1.32 and 1.77 µg/ml; tmax = 46.0, 96.0 and 84.0 min; F = 53.0, 62.0
and 80.7% after oral administration. The extent and rate of absorption from the two routes differed sign.ificantly, except for tmax at the 12.5 mg/kg dose. After compartmental analysis the pharmacokinetics of levamisole was characteristic of a two-compartment open model in 13 rabbits and of a one-compartment open model in two rabbits after subcutaneous administration, while it was two compartmental in nine and one compartmental in six rabbits after oral admini stration. The kª values were 0.321, 0.145 and 0.145 min-1 after subcutaneous
adininistration and 0.054, 0.023 and 0.027 min- 1 after oral administration. There were no significant differences between the values of Cmax• tmax and AUC calculated by compartmental and non-compartmental analysis.
SI
eng
Blackwell Scientific Publications
Ecología. Medio ambiente
Farmacología
Zoología
Bioavailability
Levamisole
Oral routes
Subcutaneous
Bioavailability of levamisole administered by subcutaneous and oral routes in rabbits
info:eu-repo/semantics/article