2024-03-28T08:24:30Zhttp://buleria.unileon.es/oai/requestoai:buleria.unileon.es:10612/45712020-12-10T09:01:37Zcom_10612_17col_10612_18
Facultad de Veterinaria
Castro, Luis J.
Sahagún, Ana M.
Diez, M. José
Fernández, Nélida
Sierra, Matilde
García, Juan J.
Farmacologia
2009-02-01
2015-09-04T11:40:03Z
2015-09-04T11:40:03Z
2015-09-04
The Veterinary Journal, 2009, n. 180
http://hdl.handle.net/10612/4571
P. 389-395
The pharmacokinetics of doxycycline were investigated in sheep after oral (PO) and intravenous (IV) administration. The IV data were
best described using a 2- (n = 5) or 3- (n = 6) compartmental open model. Mean pharmacokinetic parameters obtained using a 2-compartmental
model included a volume of distribution at steady-state (Vss) of 1.759 ± 0.3149 L/kg, a total clearance (Cl) of 3.045 ± 0.5264 mL/
kg/min and an elimination half-life (t1/2b) of 7.027 ± 1.128 h. Comparative values obtained from the 3-compartmental mean values were:
Vss of 1.801 ± 0.3429 L/kg, a Cl of 2.634 ± 0.6376 mL/kg/min and a t1/2b of 12.11 ± 2.060 h. Mean residence time (MRT0_1) was
11.18 ± 3.152 h. After PO administration, the data were best described by a 2-compartment open model. The pharmacokinetic parameter
mean values were: maximum plasma concentration (Cmax), 2.130 ± 0.950 lg/mL; time to reach Cmax (tmax), 3.595 ± 3.348 h, and absorption
half-life (t1=2k01 ), 36.28 ± 14.57 h. Non-compartmental parameter values were: Cmax, 2.182 ± 0.9117 lg/mL; tmax, 3.432 ± 3.307 h;
F, 35.77 ± 10.20%, and mean absorption time (MAT0–∞), 25.55 ± 15.27 h. These results suggest that PO administration of doxycycline
could be useful as an antimicrobial drug in sheep.
SI
eng
Elsevier
Farmacología
Veterinaria
Zoología
Pharmacokinetics
Dosycycline
Sheep
Intravenous
Oral
Pharmacokinetics of doxycycline in sheep after intravenous and oral administration
info:eu-repo/semantics/article