2024-03-28T23:02:15Zhttp://buleria.unileon.es/oai/requestoai:buleria.unileon.es:10612/134892021-10-08T00:00:29Zcom_10612_17col_10612_18
Producción Animal
Marina, Héctor
Reverter, Antonio
Gutiérrez-Gil, Beatriz
Alexandre, Pâmela Almeida
Porto-Neto, Laercio R.
Suárez-Vega, Aroa
Li, Yutao
Esteban-Blanco, Cristina
Arranz, Juan-José
Artículo de Investigación
Most of the milk produced by sheep is used for the production of high-quality cheese. Consequently, traits related to milk coagulation properties and cheese yield are economically important to the Spanish dairy industry. The present study aims to identify candidate genes and their regulators related to 14 milk and cheese-making traits and to develop a low-density panel of markers that could be used to predict an individual’s genetic potential for cheese-making efficiency. In this study, we performed a combination of the classical genome-wide association study (GWAS) with a stepwise regression method and a pleiotropy analysis to determine the best combination of the variants located within the confidence intervals of the potential candidate genes that may explain the greatest genetic variance for milk and cheese-making traits. Two gene networks related to milk and cheese-making traits were created using the genomic relationship matrices built through a stepwise multiple regression approach. Several co-associated genes in these networks are involved in biological processes previously found to be associated with milk synthesis and cheese-making efficiency. The methodology applied in this study enabled the selection of a co-association network comprised of 374 variants located in the surrounding of genes showing a potential influence on milk synthesis and cheese-making efficiency.
http://hdl.handle.net/10612/13489
spa
MDPI
Gene Networks Driving Genetic Variation in Milk and Cheese-Making Traits of Spanish Assaf Sheep
info:eu-repo/semantics/article
TEXT
BULERIA. Repositorio Institucional de la Universidad de León
Hispana