2024-03-29T06:21:42Zhttp://buleria.unileon.es/oai/requestoai:buleria.unileon.es:10612/44482020-12-10T08:58:00Zcom_10612_17col_10612_18
Farmacologia
Sierra, Matilde
García, Juan J.
Fernández, Nélida
Diez, M. José
Calle Pardo, Ángela Pilar
Álvarez, Juan C.
Carriedo, Demetrio
Castro, Luis J.
Torre, Mariano de la
González, Aranzazu
González, M. Angeles
Moran, Vicente
Prieto, Carlos
Sahagún, Ana M.
P. 830-842
The study included three phases: phase 1 (1 week), phase 2 (treatment, 14 g fibre=day, 6 weeks) and phase 3 (4 weeks).
At the end of each phase a clinical evaluation was performed after the ingestion of a test breakfast of 1824.2 kJ (436 kcal).
Measurements included concentrations of blood glucose, insulin, fructosamine, GHbA1c, C-peptide and 24 h urinary glucose
excretion. In addition, uric acid, cholesterol and several mineral and vitamin concentrations were also evaluated.
Twenty type 2 diabetic patients (12 men and 8 women) participated in the study with a mean age of 67.4 y for men
and 66 y for women. The mean body mass index of men was 28.2 kg=m2 and that of women 25.9 kg=m2.
Glucose absorption decreased significantly in the presence of psyllium (12.2%); this reduction is not associated with an
important change in insulin levels (5%). GHbA1c, C-peptide and 24 h urinary glucose excretion decreased (3.8, 14.9 and 22.5%,
respectively) during the treatment with fibre (no significant differences) as well as fructosamine (10.9%, significant differences).
Psyllium also reduced total and LDL cholesterol (7.7 and 9.2%, respectively, significant differences), and uric acid (10%,
significant difference). Minerals and vitamins did not show important changes, except sodium that increased significantly after
psyllium administration.
http://hdl.handle.net/10612/4448
spa
Nature publishing group
Therapeutic effects of psyllium in type 2 diabetic patients
info:eu-repo/semantics/article
TEXT
BULERIA. Repositorio Institucional de la Universidad de León
Hispana