2024-03-28T20:27:57Zhttp://buleria.unileon.es/oai/requestoai:buleria.unileon.es:10612/45632020-12-10T09:01:13Zcom_10612_17col_10612_18
Farmacologia
Fernández, Nélida
García, Juan J.
Sierra, Matilde
Diez, M. José
Terán, M. Teresa
2015-09-04
P. 63-66
The pharmacokinetics of levamisole at doses of 5, 7.5 and 10 mg/kg were determined after its intravenous administration to eighteen healthy Merino sheep. Using compartmental analysis, the disposition of the drug best fitted a two-compartmental open model. The mean values for the compartmental volume of distribution at steady state (Vss) were 2.034 ± 0.231, 2.347 ± 0.720 and
2.001 ± 0.367 l/kg for each dose, respectively, and values obtained using the statistical moment theory were 2.141 ± 0.269, 2.390
± 0.536 and 2.140 ± 0.345 l/kg for each dose, respectively. There were no dose-related differences (one-way ANOVA) in the constants describing distribution and elimination phases (α and β) or Vss but significant differences were detected in the total body clearance (CI) and the area under the plasma concentration-time curve (AUC). After non-compartmental analysis, no significant differences were found when the parameters λ. (the linear terminal slope) and Vss were compared, but significant differences were detected in CI and AUC. There were no significant differences between the values obtained using the compartmental and non compartmental analysis when λ.- β, CI, V,, and AUC were compared.
http://hdl.handle.net/10612/4563
spa
New Zealand veterinary association
Pharmacokinetics of levamisole in sheep after intravenous administration
info:eu-repo/semantics/article
TEXT
BULERIA. Repositorio Institucional de la Universidad de León
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